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Showing 1–2 of 2 results
Advanced filters: Author: Amir Jassim Clear advanced filters

  • Understanding how cell intrinsic and extrinsic factors combine to initiate transformation holds promise for the development of strategies to prevent, detect and treat cancer early. In this Review, Jassim et al. outline the various theories that have currently been proposed for cancer origins, and the determinants of cancer risk upon which they are based.

    • Amir Jassim
    • Eric P. Rahrmann
    • Richard J. Gilbertson
    Reviews
    Nature Reviews Cancer
    Volume: 23, P: 710-724

  • The ion channel NALCN regulates cell shedding in mice and enhances metastasis in mouse models of cancer. Disseminated cells without oncogenic mutations form normal structures at secondary sites, suggesting that cell shedding is a physiological process that is hijacked during tumorigenesis.

    • Eric P. Rahrmann
    • David Shorthouse
    • Richard J. Gilbertson
    ResearchOpen Access
    Nature Genetics
    Volume: 54, P: 1827-1838