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Showing 1–13 of 13 results
Advanced filters: Author: Amit Choudhary Clear advanced filters

  • DiNardo et al. perform a phase 1b/2 clinical trial of telaglenastat (CB-839) in combination with azacytidine in persons with advanced myelodysplastic syndromes and report on the treatment safety and efficacy, including a definition of clinical responders.

    • Courtney D. DiNardo
    • Divij Verma
    • Marina Konopleva
    Research
    Nature Cancer
    Volume: 5, P: 1515-1533

  • Proteins rely on a combination of intramolecular forces to form and stabilize their structures. A careful comparison of computational analysis and high-resolution crystal structures now indicates that the n→π* interaction merits inclusion in this group.

    • Gail J Bartlett
    • Amit Choudhary
    • Derek N Woolfson
    Research
    Nature Chemical Biology
    Volume: 6, P: 615-620

  • Current proteolysis-targeting chimeras can promote the ubiquitination and subsequent degradation of both target and off-target proteins by inducing their respective proximity with the cereblon ubiquitin ligase. Now, by developing and deploying an off-target profiling platform, ‘bumped proteolysis-targeting chimeras’ can maintain on-target degradation efficacy with reduced off-targets.

    • Tuan M. Nguyen
    • Vedagopuram Sreekanth
    • Amit Choudhary
    Research
    Nature Chemistry
    Volume: 16, P: 218-228

  • Small-molecule control of transcriptional activation and genome editing was achieved by tethering inducible protein degron domains to an engineered CRISPR–Cas9 system.

    • Basudeb Maji
    • Christopher L Moore
    • Amit Choudhary
    Research
    Nature Chemical Biology
    Volume: 13, P: 9-11

  • Lipid droplets (LDs) and peroxisomes are both generated by budding off the endoplasmic reticulum (ER). Here, the authors show that the yeast protein Pex30 marks ER subdomains where both LD and peroxisome biogenesis occurs, and identify MCTP2 as the putative mammalian Pex30 ortholog.

    • Amit S. Joshi
    • Benjamin Nebenfuehr
    • William A. Prinz
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-12

  • Cas9 fusions partners are often limited to natural polypeptide chains at the Cas9 termni. Here the authors present a platform for site-specific and multiple-site conjugation to both termini and internal sites of Cas9, and they apply this platform to efficiently engineer insulin-producing β cells.

    • Donghyun Lim
    • Vedagopuram Sreekanth
    • Amit Choudhary
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • First responders to the World Trade Center disaster, who were exposed to particulate matter containing potential carcinogens, have a high burden of somatic mutations in blood cells, raising their risk for cancer and other diseases and highlighting the need for enhanced health screening of these individuals.

    • Sakshi Jasra
    • Orsi Giricz
    • Amit Verma
    Research
    Nature Medicine
    Volume: 28, P: 468-471

  • Lim et al. developed a fluorescence resonance energy transfer-based assay to identify anti-CRISPR molecules and discovered an SpCas9 inhibitor that is twofold more efficient in inhibiting Cas9 at diverse genomic loci than existing inhibitors and easy to synthesize.

    • Donghyun Lim
    • Qingxuan Zhou
    • Amit Choudhary
    Research
    Nature Cell Biology
    Volume: 24, P: 1766-1775

  • Reduced number and function of insulin-secreting β-cells is a prominent feature of both type 1 and type 2 diabetes. Wagner and colleagues discuss strategies to promote β-cell proliferation, survival and function for the treatment of diabetes, and consider ongoing challenges to drug development efforts that are aimed at targeting this cell population.

    • Amedeo Vetere
    • Amit Choudhary
    • Bridget K. Wagner
    Reviews
    Nature Reviews Drug Discovery
    Volume: 13, P: 278-289