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Showing 1–2 of 2 results
Advanced filters: Author: Amit S Kalgutkar Clear advanced filters

  • Branched chain ketoacid dehydrogenase kinase (BDK) inhibits the activity of branched chain ketoacid dehydrogenase and branched chain amino acid degradation, implicated in several diseases. Here, the authors discover a BDK inhibitor and degrader that shows efficacy in rodent metabolism and heart failure models, as well as another class of BDK inhibitors that stabilizes BDK.

    • Rachel J. Roth Flach
    • Eliza Bollinger
    • Kevin J. Filipski
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-14

  • A single trimethylated species is obtained in an on-resin N-methylation reaction of a cyclic hexapeptide. This regioselectivity is driven by conformation and the presence of intramolecular hydrogen bonds, and is correlated with membrane permeability of the peptides.

    • Tina R White
    • Chad M Renzelman
    • R Scott Lokey
    Research
    Nature Chemical Biology
    Volume: 7, P: 810-817