Nature Search

The childhood migraine syndrome

Several childhood disorders, including infantile colic and cyclical vomiting syndrome, are thought to be related to migraine. In this Perspective, Gelfand and Abu-Arafeh present evidence for each of these disorders to be considered as part of a ‘childhood migraine syndrome’.

Ishaq Abu-Arafeh
Amy A. Gelfand
Reviews26 May 2021
Nature Reviews Neurology

Volume: 17, P: 449-458
Integrated multimodal cell atlas of Alzheimer’s disease

The affected cellular populations during Alzheimer’s disease progression remain understudied. Here the authors use a cohort of 84 donors, quantitative neuropathology and multimodal datasets from the BRAIN Initiative. Their pseudoprogression analysis revealed two disease phases.

Mariano I. Gabitto
Kyle J. Travaglini
Ed S. Lein
ResearchOpen Access14 Oct 2024
Nature Neuroscience

Volume: 27, P: 2366-2383
Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke–induced pulmonary injury and emphysema

Rubin Tuder and his colleagues show that cigarette smoke induces expression of Rtp801 (also known as Redd1), a hypoxia-inducible protein that inhibits mTOR activity and enhances oxidative stress–mediated cell death. They also show that mice deficient in Rtp801 are protected from cigarette smoke–induced lung injury, thus suggesting the protein as a target to prevent emphysema.

Toshinori Yoshida
Igor Mett
Rubin M Tuder
Research16 May 2010
Nature Medicine

Volume: 16, P: 767-773
MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study

Results from a phase 3, double-blind, randomized, placebo-controlled trial demonstrate that MDMA-assisted therapy is safe and effective in treating severe post-traumatic stress disorder.

Jennifer M. Mitchell
Michael Bogenschutz
Rick Doblin
ResearchOpen Access10 May 2021
Nature Medicine

Volume: 27, P: 1025-1033
MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial

Results from the phase 3 placebo-controlled MAPP2 trial show that MDMA-assisted therapy reduces post-traumatic stress disorder (PTSD) symptoms and functional impairment in a diverse population with moderate to severe PTSD.

Jennifer M. Mitchell
Marcela Ot’alora G.
Amy Emerson
ResearchOpen Access14 Sept 2023
Nature Medicine

Volume: 29, P: 2473-2480
Author Correction: Pan-viral serology implicates enteroviruses in acute flaccid myelitis

Ryan D. Schubert
Isobel A. Hawes
Michael R. Wilson
Amendments and Corrections21 Sept 2021
Nature Medicine

Volume: 27, P: 1849
Survey of spiking in the mouse visual system reveals functional hierarchy

A large, open dataset containing parallel recordings from six visual cortical and two thalamic areas of the mouse brain is presented, from which the relative timing of activity in response to visual stimuli and behaviour is used to construct a hierarchy scheme that corresponds to anatomical connectivity data.

Joshua H. Siegle
Xiaoxuan Jia
Christof Koch
Research20 Jan 2021
Nature

Volume: 592, P: 86-92
Genetic effects on gene expression across human tissues

Samples of different body regions from hundreds of human donors are used to study how genetic variation influences gene expression levels in 44 disease-relevant tissues.

François Aguet
Andrew A. Brown
Jingchun Zhu
ResearchOpen Access12 Oct 2017
Nature

Volume: 550, P: 204-213
Pan-viral serology implicates enteroviruses in acute flaccid myelitis

Antibodies in CSF specific for viral peptides implicate enteroviruses in acute flaccid myelitis.

Ryan D. Schubert
Isobel A. Hawes
Michael R. Wilson
Research21 Oct 2019
Nature Medicine

Volume: 25, P: 1748-1752
The impact of rare variation on gene expression across tissues

The authors show that rare genetic variants contribute to large gene expression changes across diverse human tissues and provide an integrative method for interpretation of rare variants in individual genomes.

Xin Li
Yungil Kim
Stephen B. Montgomery
ResearchOpen Access12 Oct 2017
Nature

Volume: 550, P: 239-243
Dynamic landscape and regulation of RNA editing in mammals

Using the GTEx data and others, a comprehensive analysis of adenosine-to-inosine RNA editing in mammals is presented; targets of the various ADAR enzymes are identified, as are several potential regulators of editing, such as AIMP2.

Meng How Tan
Qin Li
Jin Billy Li
Research12 Oct 2017
Nature

Volume: 550, P: 249-254
A global map of genetic diversity in Babesia microti reveals strong population structure and identifies variants associated with clinical relapse

Genomic analysis of global Babesia microti isolates reveals a population segregated into distinct geographic lineages and identifies variants in drug-binding regions of cytochrome b and ribosomal protein subunit L4 that are associated with relapsing disease.

Jacob E. Lemieux
Alice D. Tran
Pardis C. Sabeti
Research13 Jun 2016
Nature Microbiology

Volume: 1, P: 1-7
The landscape of cancer cell line metabolism

Systematic metabolite profiling across cancer cell lines uncovers patterns associated with genetic and epigenetic features and reveals dysregulated metabolic states that can be exploited for anticancer therapy

Haoxin Li
Shaoyang Ning
William R. Sellers
Research08 May 2019
Nature Medicine

Volume: 25, P: 850-860
The PET Radioligand [¹¹C]MePPEP Binds Reversibly and with High Specific Signal to Cannabinoid CB₁ Receptors in Nonhuman Primate Brain

Fumihiko Yasuno
Amira K Brown
Robert B Innis
Research28 Mar 2007
Neuropsychopharmacology

Volume: 33, P: 259-269
Candidate Genes and Risk for CP: A Population-Based Study

Yvonne W Wu
Lisa A Croen
Anthony R Torres
Research01 Dec 2011
Pediatric Research

Volume: 70, P: 642-646
Benign paroxysmal torticollis: phenotype, natural history, and quality of life

Kaitlin A. Greene
Vivien Lu
Amy A. Gelfand
Research09 Feb 2021
Pediatric Research

Volume: 90, P: 1044-1051

Search

The childhood migraine syndrome

Integrated multimodal cell atlas of Alzheimer’s disease

Rtp801, a suppressor of mTOR signaling, is an essential mediator of cigarette smoke–induced pulmonary injury and emphysema

MDMA-assisted therapy for severe PTSD: a randomized, double-blind, placebo-controlled phase 3 study

MDMA-assisted therapy for moderate to severe PTSD: a randomized, placebo-controlled phase 3 trial

Author Correction: Pan-viral serology implicates enteroviruses in acute flaccid myelitis

Survey of spiking in the mouse visual system reveals functional hierarchy

Genetic effects on gene expression across human tissues

Pan-viral serology implicates enteroviruses in acute flaccid myelitis

The impact of rare variation on gene expression across tissues

Dynamic landscape and regulation of RNA editing in mammals

A global map of genetic diversity in Babesia microti reveals strong population structure and identifies variants associated with clinical relapse

The landscape of cancer cell line metabolism

The PET Radioligand [¹¹C]MePPEP Binds Reversibly and with High Specific Signal to Cannabinoid CB₁ Receptors in Nonhuman Primate Brain

Candidate Genes and Risk for CP: A Population-Based Study

Benign paroxysmal torticollis: phenotype, natural history, and quality of life

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