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Showing 1–4 of 4 results
Advanced filters: Author: Amy K. Rines Clear advanced filters

  • The Snf1-related kinase (SNRK) is widely expressed and yet its function is poorly understood. Here the authors show that SNRK regulates mitochondrial coupling via the Trib3-PPARα-UCP3 pathway and that cardiac overexpression of SNRK decreases metabolic substrate usage and oxygen consumption but maintains cardiac function and energy in mice.

    • Amy K. Rines
    • Hsiang-Chun Chang
    • Hossein Ardehali
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-13

  • Although the liver has a key role in maintaining blood glucose homeostasis, few existing type 2 diabetes therapies directly target this organ. Here, Puigserveret al. provide an overview of the molecular mechanisms controlling hepatic gluconeogenesis and glycogen storage, focusing on emerging strategies to target hepatic glucose metabolism for the treatment of diabetes.

    • Amy K. Rines
    • Kfir Sharabi
    • Pere Puigserver
    Reviews
    Nature Reviews Drug Discovery
    Volume: 15, P: 786-804

  • Brown or beige fat activation can cause potent anti-obesity and anti-diabetic effects. In a study recently published in Nature, Gnad et al. show that adenosine is a novel activator of brown and beige fat that acts through the A2A receptor.

    • Amy K Rines
    • Francisco Verdeguer
    • Pere Puigserver
    Research Highlights
    Cell Research
    Volume: 25, P: 155-156