Nature Search

Social media use in adolescents with and without mental health conditions

Using a nationally representative UK sample of adolescents with clinical-level mental health symptoms, this Registered Report examined differences in social media use. The results suggest that adolescents with mental health conditions spent more time on social media and were less happy about online friends than adolescents without conditions.

Luisa Fassi
Amanda M. Ferguson
Amy Orben
ResearchOpen Access05 May 2025
Nature Human Behaviour

Volume: 9, P: 1283-1299
Analysis of T-cell subsets in rejection of K^b mutant skin allografts differing at class I MHC

Amy S. Rosenberg
Toshiaki Mizuochi
Alfred Singer
Research28 Aug 1986
Nature

Volume: 322, P: 829-831
Analysis of more than 400,000 women provides case-control evidence for BRCA1 and BRCA2 variant classification

BRCA1 and BRCA2 are well known breast cancer predisposition genes, however, many variants have not yet been classified for their pathogenicity. Here, the authors analyse a large combined cohort to provide evidence of variant pathogenicity.

Maria Zanti
Denise G. O’Mahony
Kyriaki Michailidou
ResearchOpen Access25 May 2025
Nature Communications

Volume: 16, P: 1-18
Mapping variants in thyroid hormone transporter MCT8 to disease severity by genomic, phenotypic, functional, structural and deep learning integration

Loss-of-function variants in thyroid hormone transporter MCT8 cause a neurodevelopmental and metabolic disorder. Here the authors identify genotype-phenotype relationships, advance insights in MCT8 (dys)function and create a pathogenicity-severity variant classifier.

Stefan Groeneweg
Ferdy S. van Geest
W. Edward Visser
ResearchOpen Access12 Mar 2025
Nature Communications

Volume: 16, P: 1-21
The circadian cryptochrome, CRY1, is a pro-tumorigenic factor that rhythmically modulates DNA repair

Cryptochrome 1 (CRY1) is a transcriptional coregulator associated with the circadian clock. Here the authors reveal that CRY1 is hormone-regulated, stabilized by genomic insult, and promotes DNA repair and cell survival through temporal transcriptional regulation.

Ayesha A. Shafi
Chris M. McNair
Karen E. Knudsen
ResearchOpen Access15 Jan 2021
Nature Communications

Volume: 12, P: 1-15
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

Claudia Langenberg, James Meigs and colleagues apply a joint meta-analysis approach that accounts for differences in body mass index to identify variants associated with glycemic traits. They report six new loci associated with fasting insulin levels and provide insights into the genetic basis of insulin resistance.

Alisa K Manning
Marie-France Hivert
Claudia Langenberg
Research13 May 2012
Nature Genetics

Volume: 44, P: 659-669
Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases

The bicyclic disulfide–containing compound thiolutin has broad antimicrobial activity and targets the essential proteasomal deubiquitinase Rpn11 and other metalloproteases, leading to inhibition of enzymatic activity through a mechanism involving zinc chelation.

Linda Lauinger
Jing Li
Axel Diernfellner
Research01 May 2017
Nature Chemical Biology

Volume: 13, P: 709-714
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

The MAGIC investigators report results of a large genome-wide association study meta-analysis to identify common variants influencing fasting glucose homeostasis. They further show that several of the newly discovered loci influencing glycemic traits are also associated with risk of type 2 diabetes.

Josée Dupuis
Claudia Langenberg
Inês Barroso
Research17 Jan 2010
Nature Genetics

Volume: 42, P: 105-116
Disruptive mutations in TANC2 define a neurodevelopmental syndrome associated with psychiatric disorders

Neurodevelopmental disorders (NDDs) are a heterogeneous group of diseases for which the genetic basis is still unknown in more than half of the cases. Here, the authors report a NDD associated with disruptive variants in the TANC2 gene and show that rols, the TANC2 homolog in flies, is required for synapse growth and function.

Hui Guo
Elisa Bettella
Evan E. Eichler
ResearchOpen Access15 Oct 2019
Nature Communications

Volume: 10, P: 1-17
mRNA-1273 protects against SARS-CoV-2 beta infection in nonhuman primates

The beta variant (B.1.351) is to date the most resistant to neutralization of the SARS-CoV-2 variants. Using nonhuman primates, Seder and colleagues demonstrate that double vaccination with a high dose of the lipid nanoparticle vaccine mRNA-1273 protects against infection with the beta variant.

Kizzmekia S. Corbett
Anne P. Werner
Robert A. Seder
Research20 Aug 2021
Nature Immunology

Volume: 22, P: 1306-1315
Mendelian Randomisation study of the influence of eGFR on coronary heart disease

Pimphen Charoen
Dorothea Nitsch
Vincent Plagno
ResearchOpen Access24 Jun 2016
Scientific Reports

Volume: 6, P: 1-8
Overexpression of SHORT VEGETATIVE PHASE-LIKE (SVL) in Populus delays onset and reduces abundance of flowering in field-grown trees

Greg S. Goralogia
Glenn T. Howe
Steven H. Strauss
ResearchOpen Access01 Aug 2021
Horticulture Research

Volume: 8, P: 1-12
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

Richard Watanabe and colleagues of the MAGIC consortium report meta-analyses of genome-wide association studies to glucose levels two hours after an oral glucose challenge. They identify variants in GIPR associated with glucose and insulin responses.

Richa Saxena
Marie-France Hivert
Richard M Watanabe
Research17 Jan 2010
Nature Genetics

Volume: 42, P: 142-148
Population genomics of Populus trichocarpa identifies signatures of selection and adaptive trait associations

Stephen DiFazio and colleagues report the genome sequences and population genomic analyses of 544 black cottonwood trees (Populus trichocarpa) along the Northwest coast of North America. They find evidence for climate-driven selection on adaptive traits, including genes related to drought, photoperiod and stress.

Luke M Evans
Gancho T Slavov
Stephen P DiFazio
Research24 Aug 2014
Nature Genetics

Volume: 46, P: 1089-1096
DataBase of Research on Prenatal Cocaine Exposure and Child Outcome † 61

Linda L LaGasse
Susan M Brunner
Barry M Lester
Research01 Apr 1998
Pediatric Research

Volume: 43, P: 13
Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

Josée Dupuis
Claudia Langenberg
Inês Barroso
Amendments and Corrections01 May 2010
Nature Genetics

Volume: 42, P: 464
Containment of transgenic trees by suppression of LEAFY

Amy L Klocko
Amy M Brunner
Steven H Strauss
Correspondence08 Sept 2016
Nature Biotechnology

Volume: 34, P: 918-922
A role for the cell-wall protein silacidin in cell size of the diatom Thalassiosira pseudonana

Amy R Kirkham
Patrick Richthammer
Thomas Mock
ResearchOpen Access21 Jul 2017
The ISME Journal

Volume: 11, P: 2452-2464
Prognostic impact of secondary versus de novo ontogeny in acute myeloid leukemia is accounted for by the European LeukemiaNet 2022 risk classification

Michael J. Hochman
Megan Othus
Judith E. Karp
ResearchOpen Access31 Jul 2023
Leukemia

Volume: 37, P: 1915-1918
p73 can suppress the proliferation of cells that express mutant p53

Amy C Willis
Tara Pipes
Xinbin Chen
Research21 Aug 2003
Oncogene

Volume: 22, P: 5481-5495
The NF-κB1 is a key regulator of acute but not chronic renal injury

Amy Fearn
Gerhard R Situmorang
Neil S Sheerin
ResearchOpen Access15 Jun 2017
Cell Death & Disease

Volume: 8, P: e2883
Finding consistency in classifications of myeloid neoplasms: a perspective on behalf of the International Workshop for Myelodysplastic Syndromes

Amer M. Zeidan
Jan Philipp Bewersdorf
Valeria Santini
Correspondence20 Oct 2022
Leukemia

Volume: 36, P: 2939-2946

Search

Social media use in adolescents with and without mental health conditions

Analysis of T-cell subsets in rejection of K^b mutant skin allografts differing at class I MHC

Analysis of more than 400,000 women provides case-control evidence for BRCA1 and BRCA2 variant classification

Mapping variants in thyroid hormone transporter MCT8 to disease severity by genomic, phenotypic, functional, structural and deep learning integration

The circadian cryptochrome, CRY1, is a pro-tumorigenic factor that rhythmically modulates DNA repair

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance

Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

Disruptive mutations in TANC2 define a neurodevelopmental syndrome associated with psychiatric disorders

mRNA-1273 protects against SARS-CoV-2 beta infection in nonhuman primates

Mendelian Randomisation study of the influence of eGFR on coronary heart disease

Overexpression of SHORT VEGETATIVE PHASE-LIKE (SVL) in Populus delays onset and reduces abundance of flowering in field-grown trees

Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge

Population genomics of Populus trichocarpa identifies signatures of selection and adaptive trait associations

DataBase of Research on Prenatal Cocaine Exposure and Child Outcome † 61

Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

Containment of transgenic trees by suppression of LEAFY

A role for the cell-wall protein silacidin in cell size of the diatom Thalassiosira pseudonana

Prognostic impact of secondary versus de novo ontogeny in acute myeloid leukemia is accounted for by the European LeukemiaNet 2022 risk classification

p73 can suppress the proliferation of cells that express mutant p53

The NF-κB1 is a key regulator of acute but not chronic renal injury

Finding consistency in classifications of myeloid neoplasms: a perspective on behalf of the International Workshop for Myelodysplastic Syndromes

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