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Showing 1–9 of 9 results
Advanced filters: Author: Amy N Abell Clear advanced filters

  • In this study, Aggarwal and colleagues perform prospective sequencing of SARS-CoV-2 isolates derived from asymptomatic student screening and symptomatic testing of students and staff at the University of Cambridge. They identify important factors that contributed to within university transmission and onward spread into the wider community.

    • Dinesh Aggarwal
    • Ben Warne
    • Ian G. Goodfellow
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • The Rho GTPase family is involved in the control of cytoskeleton dynamics, but the spatiotemporal coordination of each element (Rac1, RhoA and Cdc42) remains unknown. Here, GTPase coordination in mouse embryonic fibroblasts is examined both through simultaneous visualization of two GTPase biosensors and using a computational approach.

    • Matthias Machacek
    • Louis Hodgson
    • Gaudenz Danuser
    Research
    Nature
    Volume: 461, P: 99-103

  • Noha Shendy et al. study the role of CBP and HDAC6 in phenotypic switching using trophoblast stem cells. They identify Rel, an NF-kB family member, to be transcriptionally coregulated by CBP and HDAC6. Surprisingly, Rel induces mesenchymal-epithelial transition and itself regulated Hdac6 expression and nuclear localization.

    • Noha Ahmed Mohammed Shendy
    • Deepthi Raghu
    • Amy Noel Abell
    ResearchOpen Access
    Communications Biology
    Volume: 3, P: 1-15

  • Samples of different body regions from hundreds of human donors are used to study how genetic variation influences gene expression levels in 44 disease-relevant tissues.

    • François Aguet
    • Andrew A. Brown
    • Jingchun Zhu
    ResearchOpen Access
    Nature
    Volume: 550, P: 204-213

  • The authors show that rare genetic variants contribute to large gene expression changes across diverse human tissues and provide an integrative method for interpretation of rare variants in individual genomes.

    • Xin Li
    • Yungil Kim
    • Stephen B. Montgomery
    ResearchOpen Access
    Nature
    Volume: 550, P: 239-243

  • Using the GTEx data and others, a comprehensive analysis of adenosine-to-inosine RNA editing in mammals is presented; targets of the various ADAR enzymes are identified, as are several potential regulators of editing, such as AIMP2.

    • Meng How Tan
    • Qin Li
    • Jin Billy Li
    Research
    Nature
    Volume: 550, P: 249-254

  • Protein kinases are arguably the most tractable candidates for development of new therapies to treat cancer. Deep sequencing of breast cancer cell lines indicates each express 375 or so kinases, representing nearly 75% of the kinome. A rich network both downstream and upstream from key oncogenic kinases includes both tyrosine and serine/threonine kinases, giving plasticity and resiliency to the cancer cell kinome.

    • Alicia A Midland
    • Martin C Whittle
    • Gary L Johnson
    Research Highlights
    Cell Research
    Volume: 22, P: 620-623