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Showing 1–13 of 13 results
Advanced filters: Author: Amy Pickard Clear advanced filters

  • An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

    • Erola Pairo-Castineira
    • Konrad Rawlik
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 617, P: 764-768

  • A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

    • Mari E. K. Niemi
    • Juha Karjalainen
    • Chloe Donohue
    ResearchOpen Access
    Nature
    Volume: 600, P: 472-477

  • Whole-genome sequencing, transcriptome-wide association and fine-mapping analyses in over 7,000 individuals with critical COVID-19 are used to identify 16 independent variants that are associated with severe illness in COVID-19.

    • Athanasios Kousathanas
    • Erola Pairo-Castineira
    • J. Kenneth Baillie
    ResearchOpen Access
    Nature
    Volume: 607, P: 97-103

  • Genome-wide ancient DNA data from individuals from the Middle Bronze Age to Iron Age documents large-scale movement of people from the European continent between 1300 and 800 bc that was probably responsible for spreading early Celtic languages to Britain.

    • Nick Patterson
    • Michael Isakov
    • David Reich
    Research
    Nature
    Volume: 601, P: 588-594

  • In vitro models to study the role of host genetics in the response to chlamydial infection are limited. Here, Yeung et al. show that macrophages derived from human induced pluripotent stem cells (which can be genetically manipulated) support chlamydial infection and can be used for this purpose.

    • Amy T. Y. Yeung
    • Christine Hale
    • Robert E. W. Hancock
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12

  • Vanessa Wong and colleagues report whole-genome sequencing of 1,832 Salmonella enterica serovar Typhi isolates from 63 endemic countries. They identify mutations that define the multidrug resistant (MDR) H58 lineage and report numerous inter- and intracontinental transmissions of this lineage as well as an ongoing MDR typhoid epidemic in Africa.

    • Vanessa K Wong
    • Stephen Baker
    • Gordon Dougan
    Research
    Nature Genetics
    Volume: 47, P: 632-639

  • Ditches have many overlooked environmental and societal roles, including impact on biodiversity and pollution, and management strategies to enhance their multifunctional landscape-scale benefits are needed, according to a review of physical, biotic, chemical, and human factors.

    • Chelsea Clifford
    • Magdalena Bieroza
    • Mike Peacock
    ReviewsOpen Access
    Communications Earth & Environment
    Volume: 6, P: 1-16

  • Typhoid fever is caused by Salmonella enterica serovar Typhi (S. Typhi). This study examines ∼2,000 clinical isolates of S. Typhi to show highly structured/geographically restricted genomes except rapidly disseminating H58 subclade, and design a genotyping framework for tracking the disease.

    • Vanessa K. Wong
    • Stephen Baker
    • Ben Amos
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-11

  • The East Antarctic ice sheet retreated at the end of the last glacial period. Terrestrial and marine data suggest that the retreat began 14,000 years ago, indicating that the East Antarctic ice sheet probably did not contribute to meltwater pulse 1a 14,700 years ago.

    • Andrew Mackintosh
    • Nicholas Golledge
    • Caroline Lavoie
    Research
    Nature Geoscience
    Volume: 4, P: 195-202

  • The Schizophrenia Psychiatric Genome-Wide Association Study Consortium reports five genetic loci newly associated with risk of schizophrenia, involving 17,836 cases of schizophrenia and 33,859 healthy controls. The new locus with the strongest support of association was located within an intron for microRNA 137, a known regulator of neuronal development. Four other genome-wide significant loci for schizophrenia contain predicted targets of MIR137, suggesting that disruption to pathways involving MIR137 may be an etiologic mechanism in schizophrenia.

    • Stephan Ripke
    • Alan R Sanders
    • Pablo V Gejman
    Research
    Nature Genetics
    Volume: 43, P: 969-976