Here the authors identify that C16orf72 regulates BRCA1/Senataxin to promote replication fork recovery. These proteins act together in a pathway parallel to PARP1 to suppress R-loop accumulation in response to replication stress and confer resistance to PARP inhibitors.
- Abhishek Bharadwaj Sharma
- Muhammad Khairul Ramlee
- Nicholas D. Lakin
