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Showing 1–3 of 3 results
Advanced filters: Author: Anaïs Menny Clear advanced filters

  • To prevent unregulated complement activation, extracellular chaperones capture soluble precursors to the membrane attack complex (sMAC). Here, structural analysis of sMAC reveals how clusterin recognizes heterogeneous sMAC complexes and inhibits polymerization of complement protein C9.

    • Anaïs Menny
    • Marie V. Lukassen
    • Doryen Bubeck
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • The membrane attack complex (MAC) is a hetero-oligomeric protein assembly that kills pathogens by perforating their cell envelopes. Here, the authors use atomic force microscopy to show that MAC proteins oligomerize within the membrane, allowing them to identify the kinetic bottleneck of MAC formation.

    • Edward S. Parsons
    • George J. Stanley
    • Bart W. Hoogenboom
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-10

  • The complement membrane attack complex (MAC) is a lytic immune pore that kills pathogens. Here the authors use cryoEM to provide a structural and biophysical mechanism for how β-pore forming proteins breach the lipid bilayer, providing pathways to explore pore-formation in molecular detail.

    • Anaïs Menny
    • Marina Serna
    • Doryen Bubeck
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-11