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Showing 1–5 of 5 results
Advanced filters: Author: Ana Izcue Clear advanced filters

  • Dietary lack of a single amino acid impairs intestinal immunity in mice, altering the guts microbial community and leaving it vulnerable to damage. The finding helps to explain how malnutrition favours gut inflammation. See Letter p.477

    • Ana Izcue
    • Fiona Powrie
    News & Views
    Nature
    Volume: 487, P: 437-439

  • The accumulation of intestinal Foxp3+ regulatory T cells (Treg cells) in response to the microbiota is tightly regulated. Epithelial apoptosis inhibits the production of tolerogenic interferon-β by myeloid cells and thereby reduces the frequency of Treg cells and lowers the threshold for inflammatory responses.

    • Johanna Pott
    • Kevin J Maloy
    • Ana Izcue
    News & Views
    Nature Immunology
    Volume: 17, P: 349-350

  • Secretory immunoglobulin A (SIgA) regulates the composition and function of the gut microbiota and modulates its interaction with the host, but how this regulation is achieved is poorly understood. Now, Rollenske and colleagues profile the consequences of SIgA binding to the gut microbiota. They suggest that parallel generic and unique epitope-specific effects of SIgA regulate the intestinal microbiota.

    • Oliver Pabst
    • Ana Izcue
    News & Views
    Nature Reviews Gastroenterology & Hepatology
    Volume: 19, P: 149-150