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Showing 1–6 of 6 results
Advanced filters: Author: Ana L. Flores-Mireles Clear advanced filters

  • The authors examine temporal polymicrobial community composition in patients with long-term urinary catheters to identify species co-occurrences and demonstrate uropathogenic Escherichia coli augments growth of a prevalent opportunistic uropathogen in urine.

    • Taylor M. Nye
    • Zongsen Zou
    • Scott J. Hultgren
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-13

  • Catheter-associated urinary tract infections can often lead to secondary bloodstream infections, and catheter-induced bladder inflammation. In this work, authors utilise murine models to probe defective fibrinolysis drives extravascular fibrin formation, potentially predisposing hosts to severe CAUTI.

    • Jonathan J. Molina
    • Kurt N. Kohler
    • Ana L. Flores-Mireles
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-16

  • This Review provides a thorough comparison between uncomplicated urinary tract infections and catheter-associated urinary tract infections, highlighting that these infections are similar in terms of pathogens and sequelae, but many differences exist, for example, in pathophysiology and risk factors. The authors highlight how these differences should be considered to guide differential treatment.

    • Jonathan J. Molina
    • Ana L. Flores-Mireles
    Reviews
    Nature Reviews Urology
    P: 1-16

  • Acinetobacter baumannii is generally considered an opportunistic pathogen. Here, Di Venanzio et al. develop a mouse model of catheter-associated urinary tract infection and show that a plasmid confers niche specificity to an A. baumannii urinary isolate by regulating the expression of chromosomal genes.

    • Gisela Di Venanzio
    • Ana L. Flores-Mireles
    • Mario F. Feldman
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Urinary tract infections (UTIs) pose a severe public health problem and are caused by a range of pathogens. In this Review, Hultgren and colleagues discuss how basic science studies are elucidating the molecular mechanisms of UTI pathogenesis and how this knowledge is being used for the development of novel clinical treatments for UTIs.

    • Ana L. Flores-Mireles
    • Jennifer N. Walker
    • Scott J. Hultgren
    Reviews
    Nature Reviews Microbiology
    Volume: 13, P: 269-284