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Showing 1–3 of 3 results
Advanced filters: Author: Anais Levescot Clear advanced filters

  • Still’s disease is an inflammatory syndrome linked to the development of further immune dysregulation and hypercytokinaemia termed macrophage activation syndrome. Here the authors implicate the mechanistic target of rapamycin complex 1 in murine models of Still’s disease and macrophage activation syndrome, and provide associations with clinical cases in patients

    • Zhengping Huang
    • Xiaomeng You
    • Pui Y. Lee
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • Differentiating neutrophil functional states is difficult. Here the authors show, using single cell RNA-sequencing and trajectory analyses, that mouse neutrophils can be presented as a transcriptome continuum rather than discrete subsets, but are affected by inflammation to express distinct transcriptional states.

    • Ricardo Grieshaber-Bouyer
    • Felix A. Radtke
    • Hideyuki Yoshida
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-21

  • A high-throughput method for functional SNP identification uses enzymatic restriction to detect altered regulatory protein binding and identifies 148 candidate fSNPs associated with juvenile idiopathic arthritis, including two that regulate STAT4 via the regulatory proteins SATB2 and H1.2.

    • Gang Li
    • Marta Martínez-Bonet
    • Peter A. Nigrovic
    Research
    Nature Genetics
    Volume: 50, P: 1180-1188