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Showing 1–3 of 3 results
Advanced filters: Author: Anan Ragab Clear advanced filters

  • During the formation of vascular sprouts, Notch activation inhibits proliferation of the stalk ECs via unknown mechanism. Here the authors show that PTEN represents a critical mediator of Notch anti-proliferative response in stalk cells via its phosphatase-dependent and -independent activity.

    • Helena Serra
    • Iñigo Chivite
    • Mariona Graupera
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-13

  • Notch signals are crucial for organization of angiogenic sprouting cells into the leading ‘tip’ and trailing ‘stalk’ cells. Here the authors show that endothelial neuropilin-1 quantitatively inhibits TGF-β/BMP signalling, explaining how Notch-mediated regulation of neuropilin-1 specifies endothelial tip and stalk cells.

    • Irene Maria Aspalter
    • Emma Gordon
    • Holger Gerhardt
    ResearchOpen Access
    Nature Communications
    Volume: 6, P: 1-13

  • Cortical tension is thought to be generated by myosin II, and little is known about the role of actin network properties. Chugh et al. demonstrate that actin cortex thickness, determined by actin filament length, influences cortical tension.

    • Priyamvada Chugh
    • Andrew G. Clark
    • Ewa K. Paluch
    Research
    Nature Cell Biology
    Volume: 19, P: 689-697