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Showing 1–3 of 3 results
Advanced filters: Author: Anant Mamidi Clear advanced filters

  • Generation of the organizer tissue is induced on the dorsal side of the developing embryo by an asymmetry in Nodal signalling, which is only sufficiently high dorsally to induce organizer-specific gene expression. Now, through the identification of a microRNA (miR-15 and miR-16) that targets the Nodal receptor, microRNA is shown to have a role in this process.

    • Graziano Martello
    • Luca Zacchigna
    • Stefano Piccolo
    Research
    Nature
    Volume: 449, P: 183-188

  • In the TGFβ pathway, receptor-activated SMADs (R-SMADs) associate with SMAD4 to regulate transcription. Piccolo and colleagues reveal that the deubiquitylase USP15 is required for TGFβ responses by reversing R-SMAD ubiquitylation and thereby promoting the retention of the SMAD complex at promoters.

    • Masafumi Inui
    • Andrea Manfrin
    • Stefano Piccolo
    Research
    Nature Cell Biology
    Volume: 13, P: 1368-1375