Ferroptosis begins with phospholipid peroxidation, leading to membrane damage rupture and cell death. Although research has surged, the intracellular site for ferroptosis initiation remains uncertain. A study now identifies endoplasmic reticulum–mitochondria appositions as key hubs for phospholipid peroxides and important determinants of ferroptosis sensitivity.
- Ancély Ferreira dos Santos
- José Pedro Friedmann Angeli
