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Showing 1–6 of 6 results
Advanced filters: Author: Ancheng Huang Clear advanced filters

  • Medicinal Aconitum species produce diterpene alkaloids with diverse oxidation catalyzed by yet unknown enzymes. Luo et al. discover that divergent multifunctional P450s are key to driving oxidative diversification, yielding cryptic bioactive diterpenoids in Aconitum spp.

    • Fei Luo
    • Qian Zhou
    • Ancheng C. Huang
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15

  • Biosynthesis of antimicrobial phytoalexin glyceollins in soybean is complicated and elusive. Here Xie et al. report a plant chassis for high-yield isoflavonoid production, leading to the identification of six P450s that complete the 15-step biosynthesis of diverse glyceollins, which are critical compounds for plant defense.

    • Jiali Xie
    • Jiayu Tian
    • Ancheng C. Huang
    Research
    Nature Chemical Biology
    Volume: 21, P: 1497-1508

  • Plant roots are exposed to a diverse range of soil-dwelling microbial “friends” and “foes.” Here, via single-nucleus RNA-seq, the authors reveal cell type-specific responses to beneficial and pathogenic microbes in roots and identify regulators of root-microbiome interactions.

    • Qiuhua Yang
    • Zhuowen Li
    • Yi Song
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16

  • ATP13A2 is a lysosomal polyamine transporter, mutated in several diseases including juvenile-onset Parkinson’s disease. Here, the authors report structures of human ATP13A2 in six distinct intermediate states, illustrating most of its conformational cycle.

    • Jianqiang Mu
    • Chenyang Xue
    • Zhongmin Liu
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12

  • Sea stars and sea cucumbers biosynthesize protective glycosylated steroids and triterpenes via divergent oxidosqualene cyclases (OSCs) that produce these distinct saponins in different species as well as in different tissues of a single species.

    • Ramesha Thimmappa
    • Shi Wang
    • Anne Osbourn
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 18, P: 774-781