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Showing 1–3 of 3 results
Advanced filters: Author: Anders Gudiksen Clear advanced filters
  • Here, Miranda-Cervantes et al. identified pantothenate kinase 4 (PanK4) as a key regulator of muscle metabolism. Deleting PanK4 impairs fatty acid oxidation and glucose uptake, leading to glucose intolerance, while increasing PanK4 enhances glucose metabolism, highlighting its potential in promoting metabolic health.

    • Adriana Miranda-Cervantes
    • Andreas M. Fritzen
    • Maximilian Kleinert
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-15
  • In Greenlandic Inuit, a TBC1D4 loss-of-function mutation increases type 2 diabetes risk by tenfold. Carriers show severe muscle insulin resistance, impaired glucose disposal and reduced muscle GLUT4, yet exercise mitigates these defects, offering potential for personalized lifestyle interventions.

    • Jonas M. Kristensen
    • Rasmus Kjøbsted
    • Jørgen F. P. Wojtaszewski
    ResearchOpen Access
    Nature Metabolism
    Volume: 6, P: 2254-2266