Nature Search

Allogeneic transplantation of peripheral blood stem cell grafts results in a massive decrease of primitive hematopoietic progenitor frequencies in reconstituted bone marrows

Lambros Kordelas
André Görgens
Bernd Giebel
Research21 Aug 2019
Bone Marrow Transplantation

Volume: 55, P: 100-109
Engineering of extracellular vesicles for efficient intracellular delivery of multimodal therapeutics including genome editors

Delivering functional proteins or protein complexes into cells continues to be a significant challenge. Here, the authors develop efficient systems by using engineered extracellular vesicles to deliver functional cargoes, including CRISPR/Cas9-ribonucleoproteins, both in vitro and in vivo.

Xiuming Liang
Dhanu Gupta
Samir EL Andaloussi
ResearchOpen Access29 Apr 2025
Nature Communications

Volume: 16, P: 1-18
Author Correction: GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain

Ghulam Hassan Dar
Cláudia C. Mendes
Matthew J. A. Wood
Amendments and CorrectionsOpen Access16 Dec 2021
Nature Communications

Volume: 12, P: 1
Identification of scaffold proteins for improved endogenous engineering of extracellular vesicles

Extracellular vesicles are naturally occurring nanoparticles that are gaining ground as delivery modalities for therapeutics. Here, the authors conducted a large-scale screening programme to identify potential scaffold proteins for cargo loading into extracellular vesicles.

Wenyi Zheng
Julia Rädler
Samir EL Andaloussi
ResearchOpen Access07 Aug 2023
Nature Communications

Volume: 14, P: 1-14
Antibody-displaying extracellular vesicles for targeted cancer therapy

Extracellular vesicles decorated with an antibody-binding moiety specific for the fragment crystallizable domain can be used as a modular delivery system for targeted cancer therapy.

Oscar P. B. Wiklander
Doste R. Mamand
Samir EL Andaloussi
ResearchOpen Access20 May 2024
Nature Biomedical Engineering

Volume: 8, P: 1453-1468
Amelioration of systemic inflammation via the display of two different decoy protein receptors on extracellular vesicles

The loading of two different protein therapeutics onto extracellular vesicles can be optimized by genetically engineering the parent cells, as shown for extracellular vesicles displaying decoy receptors for two pro-inflammatory cytokines.

Dhanu Gupta
Oscar P. B. Wiklander
Samir El-Andaloussi
Research06 Oct 2021
Nature Biomedical Engineering

Volume: 5, P: 1084-1098
GAPDH controls extracellular vesicle biogenesis and enhances the therapeutic potential of EV mediated siRNA delivery to the brain

GAPDH is generally considered a housekeeping gene and functions in glycolysis. Here, the authors show that GAPDH has a role in promoting vesicle clustering in endosomes and can load siRNA onto the surface of extracellular vesicles, which can be exploited therapeutically.

Ghulam Hassan Dar
Cláudia C. Mendes
Matthew J. A. Wood
ResearchOpen Access18 Nov 2021
Nature Communications

Volume: 12, P: 1-15
Description and optimization of a multiplex bead-based flow cytometry method (MBFCM) to characterize extracellular vesicles in serum samples from patients with hematological malignancies

Lin Li
André Görgens
Helga Schmetzer
ResearchOpen Access27 Apr 2022
Cancer Gene Therapy

Volume: 29, P: 1600-1615
Human multipotent hematopoietic progenitor cell expansion is neither supported in endothelial and endothelial/mesenchymal co-cultures nor in NSG mice

Stefan Radtke
André Görgens
Bernd Giebel
ResearchOpen Access09 Sept 2019
Scientific Reports

Volume: 9, P: 1-12
Cutaneous squamous cell carcinoma-derived extracellular vesicles exert an oncogenic role by activating cancer-associated fibroblasts

Chen Li
Chengxi Sun
Andor Pivarcsi
ResearchOpen Access26 Jul 2023
Cell Death Discovery

Volume: 9, P: 1-12
Reproducible and scalable purification of extracellular vesicles using combined bind-elute and size exclusion chromatography

Giulia Corso
Imre Mäger
Samir EL Andaloussi
ResearchOpen Access14 Sept 2017
Scientific Reports

Volume: 7, P: 1-10
Enforced GFI1 expression impedes human and murine leukemic cell growth

Judith M. Hönes
Aniththa Thivakaran
Cyrus Khandanpour
ResearchOpen Access16 Nov 2017
Scientific Reports

Volume: 7, P: 1-13

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