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Evolution of enhanced innate immune evasion by SARS-CoV-2

The SARS-CoV-2 Alpha variant suppresses innate immune responses more effectively than isolates of first-wave SARS-CoV-2, and this is a result of mutations outside of the spike coding region that lead to upregulation of viral innate immune antagonists.

Lucy G. Thorne
Mehdi Bouhaddou
Nevan J. Krogan
ResearchOpen Access23 Dec 2021
Nature

Volume: 602, P: 487-495
Mapping the human genetic architecture of COVID-19

A global network of researchers was formed to investigate the role of human genetics in SARS-CoV-2 infection and COVID-19 severity; this paper reports 13 genome-wide significant loci and potentially actionable mechanisms in response to infection.

Mari E. K. Niemi
Juha Karjalainen
Chloe Donohue
ResearchOpen Access08 Jul 2021
Nature

Volume: 600, P: 472-477
Reply to: Hultström et al., Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19. Mannose-binding lectin genetics in COVID-19

Rosanna Asselta
Elvezia Maria Paraboschi
Cecilia Garlanda
Research27 May 2022
Nature Immunology

Volume: 23, P: 865-867
Crystal structure of a Src-homology 3 (SH3) domain

Andrea Musacchio
Martin Noble
Matti Saraste
Research29 Oct 1992
Nature

Volume: 359, P: 851-855
A second update on mapping the human genetic architecture of COVID-19

Masahiro Kanai
Shea J. Andrews
Matthew Solomonson
ResearchOpen Access06 Sept 2023
Nature

Volume: 621, P: E7-E26
Transit detection of the long-period volatile-rich super-Earth ν² Lupi d with CHEOPS

Three planets orbit the Sun-like star ν² Lupi. CHEOPS data show that all of them are transiting and show remarkable diversity. In particular, dry and gas-poor inner planet b has experienced extensive atmospheric loss, while planets c and d are water rich and have a small gaseous envelope of primordial origin.

Laetitia Delrez
David Ehrenreich
Nicholas A. Walton
Research28 Jun 2021
Nature Astronomy

Volume: 5, P: 775-787
The Marchantia polymorpha pangenome reveals ancient mechanisms of plant adaptation to the environment

Pangenome analyses of 133 wild accessions of the model bryophyte Marchantia polymorpha identify adaptive features and provide insights into the mechanisms of plant adaptation to the terrestrial environment.

Chloé Beaulieu
Cyril Libourel
Pierre-Marc Delaux
ResearchOpen Access17 Feb 2025
Nature Genetics

Volume: 57, P: 729-740
A multi-omics integration approach relying on circulating factors does not discern subtypes of childhood type 1 diabetes

Codazzi et al. employ multi-omics factor analysis, integrating immunome, transcriptome, and serum metabolic hormone data, to identify potential subtypes of pediatric Type 1 Diabetes. These findings reveal no significant associations, suggesting that blood-derived omics data may not suffice to identify distinct subtypes of Type 1 Diabetes.

Valentina Codazzi
Nicola Baldoni
Alessandra Petrelli
ResearchOpen Access27 May 2025
Communications Medicine

Volume: 5, P: 1-7
Retinal vascular impairment in Wolfram syndrome: an optical coherence tomography angiography study

Marco Battista
Maria Lucia Cascavilla
Piero Barboni
ResearchOpen Access08 Feb 2022
Scientific Reports

Volume: 12, P: 1-8
Publisher Correction: Evolution of enhanced innate immune evasion by SARS-CoV-2

Lucy G. Thorne
Mehdi Bouhaddou
Nevan J. Krogan
Amendments and CorrectionsOpen Access24 Mar 2022
Nature

Volume: 604, P: E14
Association between hospitalization-related outcomes, dynapenia and body mass index: The Glisten Study

Andrea P Rossi
Francesco Fantin
Giuseppina dell’Aquila
Research05 Jun 2018
European Journal of Clinical Nutrition

Volume: 73, P: 743-750
Publisher Correction: A super-Earth and two sub-Neptunes transiting the nearby and quiet M dwarf TOI-270

Maximilian N. Günther
Francisco J. Pozuelos
Ian A. Waite
Amendments and Corrections15 Aug 2019
Nature Astronomy

Volume: 3, P: 1157-1158
p140Cap inhibits β-Catenin in the breast cancer stem cell compartment instructing a protective anti-tumor immune response

The p140Cap adaptor protein is a tumour suppressor associated with improved prognosis in breast cancer. Here, the authors identify a role for p140Cap in preventing the immunosuppressive and pro-tumour function of polymorphonuclear myeloid-derived suppressor cells via downmodulation of the β-Catenin/Tumor Initiating Cells/G-CSF axi

Vincenzo Salemme
Mauro Vedelago
Paola Defilippi
ResearchOpen Access11 May 2023
Nature Communications

Volume: 14, P: 1-22
A super-Earth and two sub-Neptunes transiting the nearby and quiet M dwarf TOI-270

The Transiting Exoplanet Survey Satellite (TESS) has identified a nearby, bright, quiescent M dwarf star that hosts two sub-Neptune-sized planets and one super-Earth-sized planet. The system is eminently suitable for follow-up studies of transit timing variations, radial velocity measurements and transmission spectroscopy.

Maximilian N. Günther
Francisco J. Pozuelos
Ian A. Waite
Research29 Jul 2019
Nature Astronomy

Volume: 3, P: 1099-1108
High frequency of diabetic ketoacidosis at diagnosis of type 1 diabetes in Italian children: a nationwide longitudinal study, 2004–2013

Valentino Cherubini
Edlira Skrami
Claudia Arnaldi
ResearchOpen Access19 Dec 2016
Scientific Reports

Volume: 6, P: 1-7
A programmable closed-loop recording and stimulating wireless system for behaving small laboratory animals

Gian Nicola Angotzi
Fabio Boi
Alessandro Vato
ResearchOpen Access06 Aug 2014
Scientific Reports

Volume: 4, P: 1-11
Determinants of loss to care and risk of clinical progression in PLWH who are re-engaged in care after a temporary loss

Cristina Mussini
Patrizia Lorenzini
Enrico Girardi
ResearchOpen Access05 May 2021
Scientific Reports

Volume: 11, P: 1-13

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Evolution of enhanced innate immune evasion by SARS-CoV-2

Mapping the human genetic architecture of COVID-19

Reply to: Hultström et al., Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19. Mannose-binding lectin genetics in COVID-19

Crystal structure of a Src-homology 3 (SH3) domain

A second update on mapping the human genetic architecture of COVID-19

Transit detection of the long-period volatile-rich super-Earth ν² Lupi d with CHEOPS

The Marchantia polymorpha pangenome reveals ancient mechanisms of plant adaptation to the environment

A multi-omics integration approach relying on circulating factors does not discern subtypes of childhood type 1 diabetes

Retinal vascular impairment in Wolfram syndrome: an optical coherence tomography angiography study

Publisher Correction: Evolution of enhanced innate immune evasion by SARS-CoV-2

Association between hospitalization-related outcomes, dynapenia and body mass index: The Glisten Study

Publisher Correction: A super-Earth and two sub-Neptunes transiting the nearby and quiet M dwarf TOI-270

p140Cap inhibits β-Catenin in the breast cancer stem cell compartment instructing a protective anti-tumor immune response

A super-Earth and two sub-Neptunes transiting the nearby and quiet M dwarf TOI-270

High frequency of diabetic ketoacidosis at diagnosis of type 1 diabetes in Italian children: a nationwide longitudinal study, 2004–2013

A programmable closed-loop recording and stimulating wireless system for behaving small laboratory animals

Determinants of loss to care and risk of clinical progression in PLWH who are re-engaged in care after a temporary loss

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