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Showing 1–2 of 2 results
Advanced filters: Author: Andrea Canal-Martín Clear advanced filters

  • Dynamic combinatorial chemistry (DCC) is instrumental in the discovery of ligands for pharmaceutical targets. Here, the authors adapted DCC to work at 4 degrees Celsius and used it to identify a ligand for Neuronal Calcium Sensor-1 that promotes NCS-1/Ric8a protein-protein interaction.

    • Andrea Canal-Martín
    • Javier Sastre
    • Ruth Pérez-Fernández
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Thiol-disulfide exchange is an extensively used reversible reaction in dynamic combinatorial chemistry, but usually requires long time to reach equilibrium. Here, the authors employ selenocystine as a catalyst of thiol-disulfide exchange at low temperatures and basic pH, and show that it can promote disulfide bond formation during folding of a scrambled RNase A.

    • Andrea Canal-Martín
    • Ruth Pérez-Fernández
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12