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Reversing excitatory GABA_AR signaling restores synaptic plasticity and memory in a mouse model of Down syndrome

Both chronic and acute treatment of adult Ts65Dn mice with the FDA-approved NKCC1 inhibitor bumetanide suppressed aberrant excitatory GABA_AR signaling and rescued synaptic plasticity deficits and cognitive disabilities in this mouse model of Down syndrome.

Gabriele Deidda
Martina Parrini
Laura Cancedda
Research16 Mar 2015
Nature Medicine

Volume: 21, P: 318-326
One substrate many enzymes virtual screening uncovers missing genes of carnitine biosynthesis in human and mouse

With structural models now available on a proteome scale, Malatesta et al. show that structure-based screening can help identify proteins catalyzing orphan reactions in metabolic pathways, offering functional insights beyond sequence-based approaches.

Marco Malatesta
Emanuele Fornasier
Riccardo Percudani
ResearchOpen Access13 Apr 2024
Nature Communications

Volume: 15, P: 1-16
A light-gated potassium channel for sustained neuronal inhibition

BLINK2 is a light-activated potassium channel for optogenetic inhibition of neuronal activity. Alberio et al. apply the tool in systems as diverse as cultured rat neurons, mouse brain slices, behaving zebrafish and a rat model of neuropathic pain.

Laura Alberio
Andrea Locarno
Anna Moroni
Research30 Oct 2018
Nature Methods

Volume: 15, P: 969-976
LSD1/PRMT6-targeting gene therapy to attenuate androgen receptor toxic gain-of-function ameliorates spinobulbar muscular atrophy phenotypes in flies and mice

Here, Prakasam and colleagues show that polyQ-expanded androgen receptor toxicity can be attenuated using artificial miRNAs targeting Lsd1 and Prmt6, two AR-co-activators overexpressed in an androgen-dependent manner specifically in skeletal muscle, thus ameliorating spinal-bulbar muscular atrophy phenotypes in flies and mice.

Ramachandran Prakasam
Angela Bonadiman
Maria Pennuto
ResearchOpen Access06 Feb 2023
Nature Communications

Volume: 14, P: 1-22
Non-hyperpolarizing GABA_B receptor activation regulates neuronal migration and neurite growth and specification by cAMP/LKB1

Early neural development is regulated by the neurotransmitter GABA acting through ionotropic GABA_A receptors; however, the function of metabotropic GABA_B receptors in this context is less clear. Here the authors show that GABA_Breceptors promote neuronal migration and maturation by activating cAMP signalling.

Guillaume Bony
Joanna Szczurkowska
Laura Cancedda
Research30 Apr 2013
Nature Communications

Volume: 4, P: 1-15
Aerobic exercise and a BDNF-mimetic therapy rescue learning and memory in a mouse model of Down syndrome

Martina Parrini
Diego Ghezzi
Andrea Contestabile
ResearchOpen Access04 Dec 2017
Scientific Reports

Volume: 7, P: 1-22
Lamin B1 levels modulate differentiation into neurons during embryonic corticogenesis

Sameehan Mahajani
Caterina Giacomini
Laura Gasparini
ResearchOpen Access07 Jul 2017
Scientific Reports

Volume: 7, P: 1-11

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Reversing excitatory GABAAR signaling restores synaptic plasticity and memory in a mouse model of Down syndrome

One substrate many enzymes virtual screening uncovers missing genes of carnitine biosynthesis in human and mouse

A light-gated potassium channel for sustained neuronal inhibition

LSD1/PRMT6-targeting gene therapy to attenuate androgen receptor toxic gain-of-function ameliorates spinobulbar muscular atrophy phenotypes in flies and mice

Non-hyperpolarizing GABAB receptor activation regulates neuronal migration and neurite growth and specification by cAMP/LKB1

Aerobic exercise and a BDNF-mimetic therapy rescue learning and memory in a mouse model of Down syndrome

Lamin B1 levels modulate differentiation into neurons during embryonic corticogenesis

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Reversing excitatory GABA_AR signaling restores synaptic plasticity and memory in a mouse model of Down syndrome

Non-hyperpolarizing GABA_B receptor activation regulates neuronal migration and neurite growth and specification by cAMP/LKB1