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Gene regulatory activity associated with polycystic ovary syndrome revealed DENND1A-dependent testosterone production

Polycystic ovary syndrome (PCOS) is a common disorder, the causes of which remain incompletely understood. Here the authors report the discovery of gene regulatory mechanisms that help to explain genetic associations with PCOS in the GATA4, FSHB and DENND1A loci.

Laavanya Sankaranarayanan
Kelly J. Brewer
Timothy E. Reddy
ResearchOpen Access18 Aug 2025
Nature Communications

Volume: 16, P: 1-19
Correction: Corrigendum: Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations

M. Geoffrey Hayes
Margrit Urbanek
Andrea Dunaif
Amendments and CorrectionsOpen Access12 Feb 2016
Nature Communications

Volume: 7, P: 1
Genes, aging and sleep apnea in polycystic ovary syndrome

Polycystic ovary syndrome (PCOS) is a complex genetic disease that affects approximately 7% of women of reproductive age worldwide. From novel pathways implicated in the etiology of PCOS through genome-wide association to characterization of the reproductive and metabolic changes that occur in ageing women with PCOS, the year 2011 has seen a number of studies published that highlight the intricacies of this condition.

Andrea Dunaif
News & Views20 Dec 2011
Nature Reviews Endocrinology

Volume: 8, P: 72-74
Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations

Polycystic Ovary Sydrome is a highly heritable, complex reproductive disorder with unknown underlying genetic factors. Here Hayes and Urbanek et al. identify three loci in European women strongly associated with neuroendocrine changes and disease susceptibility.

M. Geoffrey Hayes
Margrit Urbanek
Andrea Dunaif
ResearchOpen Access18 Aug 2015
Nature Communications

Volume: 6, P: 1-13
Publisher Correction: Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations

M. Geoffrey Hayes
Margrit Urbanek
Andrea Dunaif
Amendments and CorrectionsOpen Access28 Apr 2020
Nature Communications

Volume: 11, P: 1
Drug Insight: insulin-sensitizing drugs in the treatment of polycystic ovary syndrome—a reappraisal

Insulin resistance has a pivotal role in polycystic ovary syndrome. This Review evaluates the clinical implications of findings from several recent studies on the role of insulin-sensitizing drugs, such as metformin and thiazolidinediones in polycystic ovary syndrome, with particular regard to insulin action, cardiovascular disease, hyperandrogenism, infertility and pregnancy.

Andrea Dunaif
Reviews25 Mar 2008
Nature Clinical Practice Endocrinology & Metabolism

Volume: 4, P: 272-283
Polycystic ovary syndrome

Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, ovulatory dysfunction and polycystic ovarian morphology. Here, Azziz et al. describe the current state of knowledge regarding the epidemiology, pathophysiology, diagnosis, management and future investigational directions of the disorder.

Ricardo Azziz
Enrico Carmina
Bulent O. Yildiz
Reviews11 Aug 2016
Nature Reviews Disease Primers

Volume: 2, P: 1-18

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Gene regulatory activity associated with polycystic ovary syndrome revealed DENND1A-dependent testosterone production

Correction: Corrigendum: Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations

Genes, aging and sleep apnea in polycystic ovary syndrome

Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations

Publisher Correction: Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations

Drug Insight: insulin-sensitizing drugs in the treatment of polycystic ovary syndrome—a reappraisal

Polycystic ovary syndrome

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Gene regulatory activity associated with polycystic ovary syndrome revealed DENND1A-dependent testosterone production

Correction: Corrigendum: Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations

Genes, aging and sleep apnea in polycystic ovary syndrome

Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations

Publisher Correction: Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations

Drug Insight: insulin-sensitizing drugs in the treatment of polycystic ovary syndrome—a reappraisal

Polycystic ovary syndrome

Search

Quick links