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Showing 1–16 of 16 results
Advanced filters: Author: Andrea E. Scheel Clear advanced filters

  • A large-scale multi-omics analysis reports oncogenic alterations that drive medulloblastoma progression, rather than initiation, and the findings show how single-cell technologies can be used for early detection and diagnosis of medulloblastoma.

    • Konstantin Okonechnikov
    • Piyush Joshi
    • Stefan M. Pfister
    ResearchOpen Access
    Nature
    Volume: 642, P: 1062-1072

  • We uncover key processes of the genomic evolution of small cell lung cancer under therapy, identify the common ancestor as the source of clonal diversity at relapse and show central genomic patterns associated with drug response.

    • Julie George
    • Lukas Maas
    • Roman K. Thomas
    ResearchOpen Access
    Nature
    Volume: 627, P: 880-889

  • Tightness-looseness theory predicts that social norms strengthen following threat. Here the authors test this and find that, after the emergence of the COVID-19 pandemic, hand washing norms increased, but no evidence was observed for a robust change in most other norms.

    • Giulia Andrighetto
    • Aron Szekely
    • Kimmo Eriksson
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-11

  • Radiation-induced gliomas (RIGs) have been reported in patients after treatment with cranial irradiation for various primary malignancies but their origin are still unclear. Here, the authors define the genomic, epigenetic and transcriptional landscape of 32 RIGs cases.

    • Maximilian Y. Deng
    • Dominik Sturm
    • David T. W. Jones
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • RNA-Binding Proteins (RBPs) are critical regulators of RNA biology. Here, the authors describe the Brain-pCLAP methodology, uncover the RBP atlas of the mouse brain and demonstrate the differential binding of the splicing factor RBM5 to Huntington’s disease relevant transcripts in R6/2 mice.

    • Meeli Mullari
    • Nicolas Fossat
    • Michael L. Nielsen
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-20

  • In the absence of GPX4, FSP1 regenerates ubiquinol from the oxidized form, ubiquinone, using NAD(P)H and suppresses phospholipid peroxidation and ferroptosis in cells.

    • Sebastian Doll
    • Florencio Porto Freitas
    • Marcus Conrad
    Research
    Nature
    Volume: 575, P: 693-698

  • α-ketoglutarate (αKG) is an intermediate in the tricarboxylic acid cycle that is required in the nucleus for genomic DNA demethylation by Tet3. Here, the authors show that the enzyme glutamate dehydrogenase, which converts glutamate to αKG, is redirected from the mitochondria to the nucleus.

    • Franziska R. Traube
    • Dilara Özdemir
    • Thomas Carell
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-13

  • Caloric restriction (CR) has been demonstrated to have a role in tumour growth and therapy response but its effects on cancer stem cells are less known. Here, in Acute Promyelocytic Leukemia, the authors show that despite initial anti-tumour effect, CR drives the selection of leukaemia-initiating cells resulting in relapse which could be prevented by ablation of LSD1.

    • Rani Pallavi
    • Elena Gatti
    • Pier Giuseppe Pelicci
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-18

  • Herpes simplex virus 1 (HSV-1) infection disrupts transcription termination by RNA Polymerase II. Here, Djakovic et al. identify the immediate-early protein ICP22 protein of HSV-1 to induce open chromatin downstream of genes upon read-through transcription involving the histone chaperone FACT.

    • Lara Djakovic
    • Thomas Hennig
    • Lars Dölken
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-17

  • Science strives towards a credible and comprehensive understanding of the world around us. Across disciplines within the social and behavioural sciences (and beyond), limitations in the implementation of the scientific approach have been identified in recent studies, showing low replicability of many results. This is an issue for knowledge accumulation, theory-building, and evidence-based decision and policy making. Researchers have proposed several solutions to address these issues, focusing mainly on improving statistical methods, data quality, and transparency. However, relatively little attention has been paid to another key aspect that affects replicability: language. Across fields, language plays a central role in all steps of the research cycle and is a critical communication tool among researchers. Neglecting its role may reduce replicability and limit our understanding of theoretically interesting differences and similarities across languages. After identifying these challenges, we provide some recommendations and an outlook on how replicability challenges related to language may be addressed.

    • Xenia Schmalz
    • Johannes Breuer
    • Timo Roettger
    Comments & OpinionOpen Access
    Humanities and Social Sciences Communications
    Volume: 12, P: 1-6

  • The astronomical event GW170817, detected in gravitational and electromagnetic waves, is used to determine the expansion rate of the Universe, which is consistent with and independent of existing measurements.

    • B. P. Abbott
    • R. Abbott
    • M. Serra-Ricart
    Research
    Nature
    Volume: 551, P: 85-88

  • Thirty-two experts propose ten considerations for managing the de-escalation of COVID-19 containment measures while still maintaining public adherence to social and physical distancing.

    • Katrine Bach Habersaat
    • Cornelia Betsch
    • Robb Butler
    Reviews
    Nature Human Behaviour
    Volume: 4, P: 677-687