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Mechanistic insights into alcohol-induced DNA crosslink repair by Slx4-Xpf-Ercc1 nuclease complex in the Fanconi anaemia pathway

The FA nuclease SXE (Slx4-Xpf-Ercc1) excises acetaldehyde-induced DNA interstrand crosslinks, making precise incisions to restore replication. Findings reveal SXE’s key role in FA pathway repair of alcohol- and abasic-site–linked DNA damage.

Jana Havlikova
Milan Dejmek
Jan Silhan
ResearchOpen Access26 Sept 2025
Communications Biology

Volume: 8, P: 1-11

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Mechanistic insights into alcohol-induced DNA crosslink repair by Slx4-Xpf-Ercc1 nuclease complex in the Fanconi anaemia pathway

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