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Showing 1–3 of 3 results

Advanced filters: Author: Andrea K. Byrum Clear advanced filters

The ETS transcription factor ETV6 constrains the transcriptional activity of EWS–FLI to promote Ewing sarcoma

Independent but complementary studies from Vakoc and Stegmaier identify and characterize a role for ETV6 in counteracting the transcriptional activity of EWS–FLI during Ewing sarcoma development, which may be targeted for therapeutic benefits.

Diana Y. Lu
Jana M. Ellegast
Kimberly Stegmaier
ResearchOpen Access19 Jan 2023
Nature Cell Biology

Volume: 25, P: 285-297
A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair

A signalling mechanism in human cells for sensing DNA damage induced by alkylation involves ubiquitin-dependent recruitment of the alkylation repair complex ASCC to the vicinity of the damage and co-localization with transcription and splicing factors.

Joshua R. Brickner
Jennifer M. Soll
Nima Mosammaparast
Research08 Nov 2017
Nature

Volume: 551, P: 389-393
The FLI portion of EWS/FLI contributes a transcriptional regulatory function that is distinct and separable from its DNA-binding function in Ewing sarcoma

Megann A. Boone
Cenny Taslim
Stephen L. Lessnick
ResearchOpen Access18 Jun 2021
Oncogene

Volume: 40, P: 4759-4769