Reversible mitochondrial stress leading to improved mitochondrial function (mitohormesis) has been reported as an anti-aging mechanism. Here the authors report that harmol (a beta-carboline compound) induces mitohormesis in peripheral organs, alleviates aging-related phenotypes in mice, and extends lifespan in invertebrate models.
- Luis Filipe Costa-Machado
- Esther Garcia-Dominguez
- Pablo J. Fernandez-Marcos
