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Uncoupling histone modification crosstalk by engineering lysine demethylase LSD1

Lee, Barone et al. engineered a mutant form of LSD1, Y391K, which renders the nucleosome demethylase activity of LSD1 insensitive to Lys14 acetylation of histone H3, providing a useful tool to illuminate the functional consequences of disconnecting histone modification crosstalk.

Kwangwoon Lee
Marco Barone
Philip A. Cole
Research04 Jul 2024
Nature Chemical Biology

Volume: 21, P: 227-237
PIP4K2B is mechanoresponsive and controls heterochromatin-driven nuclear softening through UHRF1

PIP4Ks are phosphoinositide kinases often dysregulated in cancer. Here Poli and colleagues find that PIP4K2B is downregulated on soft substrates, and its depletion leads to altered nuclear mechanical properties and defects in cell spreading and motility.

Alessandro Poli
Fabrizio A. Pennacchio
Paolo Maiuri
ResearchOpen Access14 Mar 2023
Nature Communications

Volume: 14, P: 1-15
Structural analysis of human SEPHS2 protein, a selenocysteine machinery component, over-expressed in triple negative breast cancer

Carmine Nunziata
Andrea Polo
Susan Costantini
ResearchOpen Access06 Nov 2019
Scientific Reports

Volume: 9, P: 1-14
Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth

Selective inhibitors of KAT6A and KAT6B inhibit MYST-catalysed histone acetylation, induce cell cycle exit and cellular senescence without causing DNA damage, and arrest lymphoma progression in mouse models.

Jonathan B. Baell
David J. Leaver
Tim Thomas
Research01 Aug 2018
Nature

Volume: 560, P: 253-257
Emerging climate-smart governance through maritime spatial planning in northern Europe

Aino Rekola
Riku Varjopuro
Bérénice Lequesne
ResearchOpen Access21 Nov 2025
npj Ocean Sustainability

Volume: 4, P: 1-11
Bromodomains: a new target class for drug development

Bromodomains are attractive targets from a chemical and structural perspective. The promising therapeutic effects of BET bromodomain inhibitors prompted chemical probe development to understand the potential of new agents targeting bromodomains. This Review discusses the next wave of bromodomain inhibitors with clinical potential in oncology and non-oncology indications.

Andrea G. Cochran
Andrew R. Conery
Robert J. Sims III
Reviews04 Jul 2019
Nature Reviews Drug Discovery

Volume: 18, P: 609-628
The opportunity for climate action through climate-smart Marine Spatial Planning

Ana M. Queirós
Talya ten Brink
Caitriona nic Aonghusa
ReviewsOpen Access21 May 2025
npj Ocean Sustainability

Volume: 4, P: 1-11

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Uncoupling histone modification crosstalk by engineering lysine demethylase LSD1

PIP4K2B is mechanoresponsive and controls heterochromatin-driven nuclear softening through UHRF1

Structural analysis of human SEPHS2 protein, a selenocysteine machinery component, over-expressed in triple negative breast cancer

Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth

Emerging climate-smart governance through maritime spatial planning in northern Europe

Bromodomains: a new target class for drug development

The opportunity for climate action through climate-smart Marine Spatial Planning

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