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Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication

Polycomb (PcG) proteins are known to promote cell proliferation by silencing expression of the tumour suppressor Ink4A-Arf. Piunti et al.show that PcG proteins also regulate tumour progression independently of this role, revealing a requirement for PRC1 and PRC2 in replication fork progression.

Andrea Piunti
Alessandra Rossi
Diego Pasini
ResearchOpen Access14 Apr 2014
Nature Communications

Volume: 5, P: 1-14
Author Correction: The roles of Polycomb repressive complexes in mammalian development and cancer

Andrea Piunti
Ali Shilatifard
Amendments and Corrections09 May 2022
Nature Reviews Molecular Cell Biology

Volume: 23, P: 444
Decoding the protein composition of whole nucleosomes with Nuc-MS

Nuc-MS makes use of top–down mass spectrometry in ‘native’ mode to quantitatively interrogate histone proteoforms and their post-translational modifications in a single experiment.

Luis F. Schachner
Kevin Jooß
Neil L. Kelleher
Research15 Feb 2021
Nature Methods

Volume: 18, P: 303-308
Uncoupling histone H3K4 trimethylation from developmental gene expression via an equilibrium of COMPASS, Polycomb and DNA methylation

A CRISPR screen for MLL2-dependent transcription identifies a compensatory repressive mechanism involving PRC2 and DNA methylation. PRC2 inactivation or DNA demethylation activates gene expression in the absence of H3K4me3.

Delphine Douillet
Christie C. Sze
Ali Shilatifard
Research11 May 2020
Nature Genetics

Volume: 52, P: 615-625
Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability

Ali Shilatifard and colleagues generate Drosophila lines expressing catalytically deficient Trr, which normally deposits H3K4me1 at enhancers. Trr mutants undergo normal development and show minimal changes in gene expression.

Ryan Rickels
Hans-Martin Herz
Ali Shilatifard
Research02 Oct 2017
Nature Genetics

Volume: 49, P: 1647-1653
Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas

Nucleosomes containing mutant K27M histones in diffuse intrinsic pediatric gliomas (DIPG) exclude PRC2 binding and recruit BET bromodomain proteins; however, residual PRC2-dependent repression of specific loci, is required for DIPG oncogenesis. These results provide a rationale for targeting these epigenetic regulators in patients.

Andrea Piunti
Rintaro Hashizume
Ali Shilatifard
Research27 Feb 2017
Nature Medicine

Volume: 23, P: 493-500
The roles of Polycomb repressive complexes in mammalian development and cancer

The histone modifiers Polycomb repressive complex 1 (PRC1) and PRC2 have important roles in development and disease, especially cancer. Recent studies have revealed the existence of various mutually exclusive PRC1 and PRC2 variants, and provided new insights into their molecular functions and physiological importance.

Andrea Piunti
Ali Shilatifard
Reviews15 Mar 2021
Nature Reviews Molecular Cell Biology

Volume: 22, P: 326-345

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Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication

Author Correction: The roles of Polycomb repressive complexes in mammalian development and cancer

Decoding the protein composition of whole nucleosomes with Nuc-MS

Uncoupling histone H3K4 trimethylation from developmental gene expression via an equilibrium of COMPASS, Polycomb and DNA methylation

Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability

Therapeutic targeting of polycomb and BET bromodomain proteins in diffuse intrinsic pontine gliomas

The roles of Polycomb repressive complexes in mammalian development and cancer

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