Turrell et al. show that, in young mice, low-level PDGF-C expression maintains dormancy of disseminated tumor cells, but, in aged or fibrotic lungs, the PDGF-C-high environment promotes proliferation, which can be counteracted with inhibition of PDGFRα or PDGF-C blockade.
- Frances K. Turrell
- Rebecca Orha
- Clare M. Isacke
