Nature Search

High temperature and nib acidification during cacao-controlled fermentation improve cadmium transfer from nibs to testa and the liquor’s flavor

Ivan D. Camargo
Lucero G. Rodriguez-Silva
Lucas F. Quintana-Fuentes
ResearchOpen Access28 May 2024
Scientific Reports

Volume: 14, P: 1-16
The giant diploid faba genome unlocks variation in a global protein crop

Using a high-quality chromosome-scale assembly of the faba bean genome, the genetic basis of seed size and hilum colour is explored.

Murukarthick Jayakodi
Agnieszka A. Golicz
Stig Uggerhøj Andersen
ResearchOpen Access08 Mar 2023
Nature

Volume: 615, P: 652-659
Natural swarms in 3.99 dimensions

Tests of the predictions of the renormalization group in biological experiments have not yet been decisive. Now, a study on the collective dynamics of insect swarms provides a long-sought match between experiment and theory.

Andrea Cavagna
Luca Di Carlo
Mattia Scandolo
ResearchOpen Access24 Apr 2023
Nature Physics

Volume: 19, P: 1043-1049
Plastic to apparel: an analysis of sustainable purchasing intention using a machine learning ensemble

Carmella Andrea L. Cabrera
Ardvin Kester S. Ong
Ma. Janice J. Gumasing
ResearchOpen Access14 Jun 2025
Humanities and Social Sciences Communications

Volume: 12, P: 1-18
Dormancy-break and germination requirements for seeds of the threatened Austral papaya (Carica chilensis)

Andrea P. Loayza
Patricio García-Guzmán
Danny E. Carvajal
ResearchOpen Access13 Oct 2023
Scientific Reports

Volume: 13, P: 1-7
Direct modulation of Aplysia S-K⁺ channels by a 12-lipoxygenase metabolite of arachidonic acid

Ned Buttner
Steven A. Siegelbaum
Andrea Volterra
Research30 Nov 1989
Nature

Volume: 342, P: 553-555
Affinity for both sides

DNA-encoded libraries are a powerful tool to identify novel chemical inducers of proximity such as targeted protein degraders, even without a known binder for the target protein.

Andrea Testa
News & Views02 Nov 2023
Nature Chemical Biology

Volume: 20, P: 134-135
Sustained enzymatic activity and flow in crowded protein droplets

Living cells can harvest environmental energy to drive chemical processes. Here the authors design a minimal artificial system that achieves steady states at similar metabolic densities to microorganisms.

Andrea Testa
Mirco Dindo
Paola Laurino
ResearchOpen Access01 Nov 2021
Nature Communications

Volume: 12, P: 1-8
Targeted protein degradation via intramolecular bivalent glues

Studies using genetic screening, biophysical characterization and structural reconstitution elucidate the mechanism of action and enable rational design of a new class of functional compounds that glue target proteins to E3 ligases via intramolecularly bridging two domains to enhance intrinsic protein–protein interactions and promote target ubiquitination and degradation.

Oliver Hsia
Matthias Hinterndorfer
Alessio Ciulli
ResearchOpen Access21 Feb 2024
Nature

Volume: 627, P: 204-211
Polycomb proteins control proliferation and transformation independently of cell cycle checkpoints by regulating DNA replication

Polycomb (PcG) proteins are known to promote cell proliferation by silencing expression of the tumour suppressor Ink4A-Arf. Piunti et al.show that PcG proteins also regulate tumour progression independently of this role, revealing a requirement for PRC1 and PRC2 in replication fork progression.

Andrea Piunti
Alessandra Rossi
Diego Pasini
ResearchOpen Access14 Apr 2014
Nature Communications

Volume: 5, P: 1-14
A control oriented strategy of disruption prediction to avoid the configuration collapse of tokamak reactors

Confining plasma and managing disruptions in tokamak devices is a challenge. Here the authors demonstrate a method predicting and possibly preventing disruptions and macroscopic instabilities in tokamak plasma using data from JET.

Andrea Murari
Riccardo Rossi
Michela Gelfusa
ResearchOpen Access18 Mar 2024
Nature Communications

Volume: 15, P: 1-19
Extending fluorescence anisotropy to large complexes using reversibly switchable proteins

STARSS measures rotational dynamics of large molecules and their complexes.

Andrea Volpato
Dirk Ollech
Ilaria Testa
ResearchOpen Access10 Oct 2022
Nature Biotechnology

Volume: 41, P: 552-559
Epigenomic landscape of human colorectal cancer unveils an aberrant core of pan-cancer enhancers orchestrated by YAP/TAZ

The role of epigenetic deregulation in colorectal cancer (CRC) is not fully understood yet. Here the authors use patient-derived organoids, epigenomics and single-cell RNA-seq to reveal that YAP/TAZ are key regulators that bind to active enhancers in CRC and promote tumour survival.

Giulia Della Chiara
Federica Gervasoni
Massimiliano Pagani
ResearchOpen Access20 Apr 2021
Nature Communications

Volume: 12, P: 1-18
Phase-separated droplets swim to their dissolution

Here the authors identify a generic coupling in phase-separated liquids between motility and phase equilibria perturbations: phase-separated droplets swim to their dissolution. This suggests alternative transport mechanism for biomolecular condensates.

Etienne Jambon-Puillet
Andrea Testa
Eric R. Dufresne
ResearchOpen Access09 May 2024
Nature Communications

Volume: 15, P: 1-12
Voretigene neparvovec for inherited retinal dystrophy due to RPE65 mutations: a scoping review of eligibility and treatment challenges from clinical trials to real practice

Francesco Testa
Giacomo Bacci
Francesca Simonelli
ReviewsOpen Access16 Apr 2024
Eye

Volume: 38, P: 2504-2515
Single-nucleus RNA sequencing reveals glial cell type-specific responses to ischemic stroke in male rodents

Ischemic stroke, caused by sudden oxygen and substrate deprivation of the CNS, is a leading cause of disability and death. Here, the authors characterize in a rodent model the molecular signature of glial cells in response to ischemic stroke at single cell resolution.

Daniel Bormann
Michael Knoflach
Michael Mildner
ResearchOpen Access24 Jul 2024
Nature Communications

Volume: 15, P: 1-23
Genetic separation of Brca1 functions reveal mutation-dependent Polθ vulnerabilities

Homologous recombination (HR) gene mutations are thought to be synthetic lethal with DNA polymerase theta (Polθ) inhibition. Here, the authors reveal that Polθ addiction is determined by the functional impact of gene mutations on DNA end resection activity.

John J. Krais
David J. Glass
Neil Johnson
ResearchOpen Access24 Nov 2023
Nature Communications

Volume: 14, P: 1-13
RagD auto-activating mutations impair MiT/TFE activity in kidney tubulopathy and cardiomyopathy syndrome

Mutations in the RRAGD gene are causative of an autosomal dominant disorder characterized by kidney tubulopathy and cardiomyopathy. Here, the authors identify a new RRAGD P88L mutation, demonstrating that all the identified RRAGD mutations inhibit the nuclear translocation of MiT/TFE transcription factors, resulting in defective responses to lysosomal or mitochondrial damage.

Irene Sambri
Marco Ferniani
Andrea Ballabio
ResearchOpen Access15 May 2023
Nature Communications

Volume: 14, P: 1-13
Structural basis of PROTAC cooperative recognition for selective protein degradation

The description of the crystal structure of the Brd4 PROTAC compound MZ1 in complex with the human E3 ubiquitin ligase VHL and the Brd4 bromodomain shines new light onto how PROTACs work and enables design of degraders with increased selectivity for Brd4.

Morgan S Gadd
Andrea Testa
Alessio Ciulli
Research13 Mar 2017
Nature Chemical Biology

Volume: 13, P: 514-521
Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network

Mammalian genomes are scattered with repetitive sequences, but their biology remains largely elusive. Here, the authors show that transcription can initiate from short tandem repetitive sequences, and that genetic variants linked to human diseases are preferentially found at repeats with high transcription initiation level.

Mathys Grapotte
Manu Saraswat
Charles-Henri Lecellier
ResearchOpen Access02 Jun 2021
Nature Communications

Volume: 12, P: 1-18
Hospital costs of robotic-assisted and open treatment of large ventral hernias

Flaminia Sabbatini
Davide La Regina
Francesco Mongelli
ResearchOpen Access21 May 2024
Scientific Reports

Volume: 14, P: 1-7
Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms

tag-Targeted Protein Degrader (tTPD) systems are powerful tools for preclinical target validation. Here the authors extend the tTPD platform by developing NanoTACs that degrade NanoLuc tagged substrates and benchmark each tTPD system using an interchangeable tag reporter system.

Christoph Grohmann
Charlene M. Magtoto
Rebecca Feltham
ResearchOpen Access19 Apr 2022
Nature Communications

Volume: 13, P: 1-13
Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2

SH2 domains are challenging to target using small molecules. Here, the authors develop phosphotyrosine-based covalent ligands of the E3 ligase SOCS2 using structure-based design. A pro-drug approach yields cell active inhibitors that block SOCS2 substrate recruitment.

Sarath Ramachandran
Nikolai Makukhin
Alessio Ciulli
ResearchOpen Access10 Oct 2023
Nature Communications

Volume: 14, P: 1-17
Smart lattice light-sheet microscopy for imaging rare and complex cellular events

smartLLSM uses artificial intelligence-based instrument control to switch between epiflouorescence and lattice light-sheet microscopy to monitor cells at the population level while also capturing multicolor three-dimensional datasets of rare events of interest.

Yu Shi
Jimmy S. Tabet
Wesley R. Legant
Research02 Jan 2024
Nature Methods

Volume: 21, P: 301-310
Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders

Coupling haploid genetics with deep scanning mutagenesis, Hanzl et al. identified functional hotspots in E3 ubiquitin ligases that are selectively required for different proteolysis-targeting chimeras (PROTACs) or molecular glue degraders and found mutated in relapsing patients.

Alexander Hanzl
Ryan Casement
Georg E. Winter
Research03 Nov 2022
Nature Chemical Biology

Volume: 19, P: 323-333
Detection of impending reflex syncope by means of an integrated multisensor patch-type recorder

Antonella Groppelli
Martina Rafanelli
Gianfranco Parati
Research19 May 2023
Journal of Human Hypertension

Volume: 37, P: 1098-1104
The neuroepithelial origin of ovarian carcinomas explained through an epithelial-mesenchymal-ectodermal transition enhanced by cisplatin

David Díaz-Carballo
Ayesha Safoor
Dirk Strumberg
ResearchOpen Access26 Nov 2024
Scientific Reports

Volume: 14, P: 1-34
Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity

Trivalent PROTACs are reported as a strategy to increase protein degradation efficacy and therapeutic window by combining avidity of target engagement with cooperativity to form highly favorable and productive ternary complexes.

Satomi Imaide
Kristin M. Riching
Alessio Ciulli
Research21 Oct 2021
Nature Chemical Biology

Volume: 17, P: 1157-1167
Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation

Targeting the ubiquitin proteasome system to modulate protein homeostasis using small molecules has promising therapeutic potential. Here the authors describe Homo-PROTACS: small molecules that can induce the homo-dimerization of E3 ubiquitin ligases and cause their proteasome-dependent degradation.

Chiara Maniaci
Scott J. Hughes
Alessio Ciulli
ResearchOpen Access10 Oct 2017
Nature Communications

Volume: 8, P: 1-14
Super-resolution microscopy compatible fluorescent probes reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics

Glucagon-like peptide-1 receptor is an important regulator of appetite and glucose homeostasis. Here the authors describe super-resolution microscopy and in vivo imaging compatible fluorescent probes, which reveal endogenous glucagon-like peptide-1 receptor distribution and dynamics in islets and brain.

Julia Ast
Anastasia Arvaniti
David J. Hodson
ResearchOpen Access24 Jan 2020
Nature Communications

Volume: 11, P: 1-18
Mutant p53 induces Golgi tubulo-vesiculation driving a prometastatic secretome

p53 mutants can promote tumorigenesis by affecting fundamental cellular pathways and functions. In this study, the authors demonstrate a novel mutant-p53/HIF1α/miR-30d axis that impacts Golgi structure, trafficking, and secretion of proteins essential for tumor growth and metastasis.

Valeria Capaci
Lorenzo Bascetta
Giannino Del Sal
ResearchOpen Access07 Aug 2020
Nature Communications

Volume: 11, P: 1-19
Acylphosphatase is involved in differentiation of K562 cells

Paola Chiarugi
Donatella Degl'Innocenti
Giampietro Ramponi
Research01 May 1997
Cell Death & Differentiation

Volume: 4, P: 334-340
Metabolic control of YAP and TAZ by the mevalonate pathway

Del Sal and colleagues demonstrate that the YAP and TAZ effectors of the Hippo pathway are under the control of the mevalonate pathway. They show that mutant p53 and SREBP-dependent activation of mevalonate signalling activates YAP and TAZ and promotes tumour formation in mice, a growth phenotype also conserved in Drosophila.

Giovanni Sorrentino
Naomi Ruggeri
Giannino Del Sal
Research23 Mar 2014
Nature Cell Biology

Volume: 16, P: 357-366
Th1/Th2 polarization of peripheral immune response in atherothrombotic and cardioembolic stroke: a prospective study

Simone Bellavia
Irene Scala
Giovanni Frisullo
ResearchOpen Access30 Sept 2022
Scientific Reports

Volume: 12, P: 1-6
Publisher Correction: LifeTime and improving European healthcare through cell-based interceptive medicine

Nikolaus Rajewsky
Geneviève Almouzni
Frauke Zipp
Amendments and CorrectionsOpen Access17 Mar 2021
Nature

Volume: 592, P: E8
Dynamics of cocoa fermentation and its effect on quality

Ana M. Calvo
Blanca L. Botina
Jenifer Criollo
ResearchOpen Access18 Aug 2021
Scientific Reports

Volume: 11, P: 1-15
Active fixation as an efficient coding strategy for neuromorphic vision

Simone Testa
Silvio P. Sabatini
Andrea Canessa
ResearchOpen Access08 May 2023
Scientific Reports

Volume: 13, P: 1-14
Social epidemiology of early adolescent nutrition

Jason M. Nagata
Christiane K. Helmer
Andrea K. Garber
ResearchOpen Access27 Jan 2025
Pediatric Research

Volume: 98, P: 885-894
Author Correction: Discovery of widespread transcription initiation at microsatellites predictable by sequence-based deep neural network

Mathys Grapotte
Manu Saraswat
Charles-Henri Lecellier
Amendments and CorrectionsOpen Access01 Mar 2022
Nature Communications

Volume: 13, P: 1
A restricted signature of miRNAs distinguishes APL blasts from normal promyelocytes

S Careccia
S Mainardi
M G Rizzo
Research14 Sept 2009
Oncogene

Volume: 28, P: 4034-4040
A machine-learning parsimonious multivariable predictive model of mortality risk in patients with Covid-19

Rita Murri
Jacopo Lenkowicz
Lorenzo Zileri Dal Verme
ResearchOpen Access27 Oct 2021
Scientific Reports

Volume: 11, P: 1-10
LifeTime and improving European healthcare through cell-based interceptive medicine

The LifeTime initiative is an ambitious, multidisciplinary programme that aims to improve healthcare by tracking individual human cells during disease processes and responses to treatment in order to develop and implement cell-based interceptive medicine in Europe.

Nikolaus Rajewsky
Geneviève Almouzni
Frauke Zipp
Reviews07 Sept 2020
Nature

Volume: 587, P: 377-386
Intravitreal bevacizumab in the successful management of choroidal metastases secondary to lung and breast cancer unresponsive to systemic therapy: a case series

V Fenicia
S Abdolrahimzadeh
S M Recupero
Research25 Apr 2014
Eye

Volume: 28, P: 888-891
A gene toolbox for monitoring autophagy transcription

Matteo Bordi
Rossella De Cegli
Francesco Cecconi
ResearchOpen Access02 Nov 2021
Cell Death & Disease

Volume: 12, P: 1-7
Effects of intracellular calcium accumulation on proteins encoded by the major genes underlying amyotrophic lateral sclerosis

Giovanni De Marco
Annarosa Lomartire
Andrea Calvo
ResearchOpen Access10 Jan 2022
Scientific Reports

Volume: 12, P: 1-14
Differential diagnosis of neurodegenerative dementias with the explainable MRI based machine learning algorithm MUQUBIA

Silvia De Francesco
Claudio Crema
Fabio Maria Triulzi
ResearchOpen Access13 Oct 2023
Scientific Reports

Volume: 13, P: 1-19
Impact of SPRINT results on hypertension guidelines: implications for “frail” elderly patients

Gennaro Russo
Ilaria Liguori
Pasquale Abete
Reviews10 Jul 2018
Journal of Human Hypertension

Volume: 32, P: 633-638
miRNA let-7c promotes granulocytic differentiation in acute myeloid leukemia

A Pelosi
S Careccia
M G Rizzo
Research10 Sept 2012
Oncogene

Volume: 32, P: 3648-3654
Resolving the dark matter of ABCA4 for 1054 Stargardt disease probands through integrated genomics and transcriptomics

Mubeen Khan
Stéphanie S. Cornelis
Frans P. M. Cremers
Research20 Apr 2020
Genetics in Medicine

Volume: 22, P: 1235-1246
Upper limb joint kinematics using wearable magnetic and inertial measurement units: an anatomical calibration procedure based on bony landmark identification

Pietro Picerno
Pietro Caliandro
Andrea Cereatti
ResearchOpen Access08 Oct 2019
Scientific Reports

Volume: 9, P: 1-10

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