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Publisher Correction: Long-term functional and structural preservation of precision-cut human myocardium under continuous electromechanical stimulation in vitro

Carola Fischer
Hendrik Milting
Andreas Dendorfer
Amendments and CorrectionsOpen Access28 Jan 2019
Nature Communications

Volume: 10, P: 1
Long-term functional and structural preservation of precision-cut human myocardium under continuous electromechanical stimulation in vitro

Myocardial tissue undergoes steady functional decline when cultured in vitro. Here, the authors report a protocol for culture of human cardiac slices that allows maintenance of contractility for up to four months, and show that the model is suitable for evaluation of drug safety, as exemplified for drugs interfering with cardiomyocyte repolarization.

Carola Fischer
Hendrik Milting
Andreas Dendorfer
ResearchOpen Access10 Jan 2019
Nature Communications

Volume: 10, P: 1-12
DNMT3A clonal hematopoiesis-driver mutations induce cardiac fibrosis by paracrine activation of fibroblasts

This study uncovers a critical link between DNMT3A-driven CHIP and heart failure and, in particular, it shows that DNMT3A inactivation in monocytes boosts the release of HB-EGF, which activates fibroblasts inducing diffuse fibrosis in the heart.

Mariana Shumliakivska
Guillermo Luxán
Stefanie Dimmeler
ResearchOpen Access19 Jan 2024
Nature Communications

Volume: 15, P: 1-20
Identification and functional analysis of novel THAP1 mutations

Katja Lohmann
Nils Uflacker
Norbert Brüggemann
Research17 Aug 2011
European Journal of Human Genetics

Volume: 20, P: 171-175
Cardiac-specific deletion of voltage dependent anion channel 2 leads to dilated cardiomyopathy by altering calcium homeostasis

The authors found that VDAC2 plays a crucial role in influencing mitochondrial calcium dynamics and cellular calcium signalling. A VDAC2 agonist, efsevin, rescued the heart failure phenotype, identifying a new potential therapeutic target for heart failure.

Thirupura S. Shankar
Dinesh K. A. Ramadurai
Stavros G. Drakos
ResearchOpen Access28 Jul 2021
Nature Communications

Volume: 12, P: 1-15
MicroRNA-365 regulates human cardiac action potential duration

An abnormal cardiac action potential underlies different types of cardiac arrhythmias. Here the authors show that microRNA-365 regulates the cardiac action potential by modulating key cardiac repolarizing channels.

Dena Esfandyari
Bio Maria Ghéo Idrissou
Stefan Engelhardt
ResearchOpen Access11 Jan 2022
Nature Communications

Volume: 13, P: 1-15
Migratory and anti-fibrotic programmes define the regenerative potential of human cardiac progenitors

In this study, the authors report that pluripotent stem cell-derived ventricular progenitors target loss of myocardium and fibrotic scarring to promote heart regeneration, thus offering new potential therapeutic strategies for heart injury.

Christine M. Poch
Kylie S. Foo
Karl-Ludwig Laugwitz
ResearchOpen Access12 May 2022
Nature Cell Biology

Volume: 24, P: 659-671
Synchronous force and Ca²⁺ measurements for repeated characterization of excitation-contraction coupling in human myocardium

The authors present a Ca²⁺ imaging method based on visible light and ratiometric dye, which permits motion-corrected assessment of Ca²⁺ transients in parallel with contraction force in cultured slices of human living myocardium.

Zhengwu Sun
Kun Lu
Andreas Dendorfer
ResearchOpen Access22 Feb 2024
Communications Biology

Volume: 7, P: 1-10

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Publisher Correction: Long-term functional and structural preservation of precision-cut human myocardium under continuous electromechanical stimulation in vitro

Long-term functional and structural preservation of precision-cut human myocardium under continuous electromechanical stimulation in vitro

DNMT3A clonal hematopoiesis-driver mutations induce cardiac fibrosis by paracrine activation of fibroblasts

Identification and functional analysis of novel THAP1 mutations

Cardiac-specific deletion of voltage dependent anion channel 2 leads to dilated cardiomyopathy by altering calcium homeostasis

MicroRNA-365 regulates human cardiac action potential duration

Migratory and anti-fibrotic programmes define the regenerative potential of human cardiac progenitors

Synchronous force and Ca²⁺ measurements for repeated characterization of excitation-contraction coupling in human myocardium

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