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Showing 1–6 of 6 results
Advanced filters: Author: Andreas Ettinger Clear advanced filters

  • During cell division, a cytoplasmic bridge—the midbody—forms between the nascent daughter cells, but it has been unclear under which conditions this is retained by a daughter cell or released. Now, Ettinger and colleagues show that midbody-release occurs more frequently in stem cells compared with cancer cells.

    • Andreas W. Ettinger
    • Michaela Wilsch-Bräuninger
    • Wieland B. Huttner
    ResearchOpen Access
    Nature Communications
    Volume: 2, P: 1-12

  • Genome-wide replication timing maps of mouse embryos from the zygote to the blastocyst stage were generated using single-cell Repli-seq, shedding light on the establishment of the epigenome at the beginning of mammalian development.

    • Tsunetoshi Nakatani
    • Tamas Schauer
    • Maria-Elena Torres-Padilla
    ResearchOpen Access
    Nature
    Volume: 625, P: 401-409

  • Totipotent cells in mouse embryos and 2-cell-like cells have slow DNA replication fork speed. Perturbations that slow replication fork speed promote 2-cell-like cell emergence and improve somatic cell nuclear transfer reprogramming and formation of induced pluripotent stem cell colonies.

    • Tsunetoshi Nakatani
    • Jiangwei Lin
    • Maria-Elena Torres-Padilla
    ResearchOpen Access
    Nature Genetics
    Volume: 54, P: 318-327

  • van Haren et al. develop a tool to rapidly dissociate proteins from the growing end of microtubules through photo-induced disassembly of end-binding protein 1 (EB1), and find that this reduces microtubule growth and alters cell migration.

    • Jeffrey van Haren
    • Rabab A. Charafeddine
    • Torsten Wittmann
    Research
    Nature Cell Biology
    Volume: 20, P: 252-261

  • Wittmann and colleagues demonstrate that the turnover of mature focal adhesions is regulated by CLASP proteins. They show that CLASP recruitment to focal adhesions is involved in localized exocytosis and extracellular matrix degradation, suggesting that local matrix metalloprotease secretion might promote focal adhesion disassembly.

    • Samantha J. Stehbens
    • Matthew Paszek
    • Torsten Wittmann
    Research
    Nature Cell Biology
    Volume: 16, P: 558-570

  • Maliga and colleagues have produced a library of bacterial artificial chromosome (BAC) transgenes encoding tagged human kinesin and myosin motors, and have generated a collection of BAC-expressing human and mouse cell lines for the study of motor function.

    • Zoltan Maliga
    • Magno Junqueira
    • Anthony A. Hyman
    Research
    Nature Cell Biology
    Volume: 15, P: 325-334