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Showing 1–5 of 5 results
Advanced filters: Author: Andreas Henseler Clear advanced filters

  • End-stage heart failure remains a major clinical challenge with limited effective treatments. Here, the authors present a concept for a soft robotic total artificial heart with a biocompatible inner lining that shows native-like functions

    • Maziar Arfaee
    • Annemijn Vis
    • Jolanda Kluin
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14

  • The authors defined a roadmap for investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders. Their proof-of-concept study using the largest available common variant data sets for schizophrenia and volumes of several (mainly subcortical) brain structures did not find evidence of genetic overlap.

    • Barbara Franke
    • Jason L Stein
    • Patrick F Sullivan
    Research
    Nature Neuroscience
    Volume: 19, P: 420-431

  • In a GWAS study of 32,438 adults, the authors discovered five novel loci for intracranial volume and confirmed two known signals. Variants for intracranial volume were also related to childhood and adult cognitive function and to Parkinson's disease, and enriched near genes involved in growth pathways, including PI3K-AKT signaling.

    • Hieab H H Adams
    • Derrek P Hibar
    • Paul M Thompson
    Research
    Nature Neuroscience
    Volume: 19, P: 1569-1582

  • The Collaborative Association Study of Psoriasis, in partnership with the Genetic Association Information Network (GAIN), reports a genome-wide association study for psoriasis. They identify new replicated associations that highlight a role for the IL-23 and NF-κB pathways in psoriasis susceptibility.

    • Rajan P Nair
    • Kristina Callis Duffin
    • Gonçalo R Abecasis
    Research
    Nature Genetics
    Volume: 41, P: 199-204

  • Richard Trembath and colleagues report a meta-analysis of genome-wide association studies for psoriasis, including 2 cohorts genotyped on the custom Immunochip array, in a total of 10,588 cases and 22,806 controls. They identify 15 new susceptibility loci and refine signals in previously known loci, highlighting a role for innate host defense in susceptibility to psoriasis.

    • Lam C Tsoi
    • Sarah L Spain
    • Richard C Trembath
    Research
    Nature Genetics
    Volume: 44, P: 1341-1348