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Showing 1–4 of 4 results
Advanced filters: Author: Andreas K. Brödel Clear advanced filters

  • Genetic circuits usually employ the same set of transcription factors which can act via repression or activation of the target promoter. Here the authors present dual activator-repressor switches, designed via directed evolution, for orthogonal logic gates and multi-input circuit architectures.

    • Andreas K. Brödel
    • Alfonso Jaramillo
    • Mark Isalan
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-9

  • Edited bacteria were stably maintained in mouse gut for at least 42 days following the delivery of a base editor using an engineered phage-derived particle to modify Escherichia coli colonizing the gut.

    • Andreas K. Brödel
    • Loïc H. Charpenay
    • David Bikard
    ResearchOpen Access
    Nature
    Volume: 632, P: 877-884

  • Bioengineers have used directed evolution to generate a new family of synthetic transcription factors based on the tryptophan repressor. The evolved repressor family enables researchers to build new gene circuits for biomedical applications.

    • Andreas K. Brödel
    • Mark Isalan
    News & Views
    Nature Chemical Biology
    Volume: 14, P: 328-329