c-di-GMP has emerged as the signal controlling development in antibiotic producing Streptomyces. Here the authors describe another developmental role of c-di-GMP, in energy metabolism, by activating the glycogen-debranchingenzyme, GlgX. Structures revealing the activation mechanism are described.
- Maria A. Schumacher
- Mirka E. Wörmann
- Natalia Tschowri