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Showing 1–9 of 9 results
Advanced filters: Author: Andreas Michael Zeiher Clear advanced filters

  • In individuals with long-term cardiac symptoms after an initially mild course of COVID-19 illness, magnetic resonance imaging and measurement of cardiac injury biomarkers commonly detected ongoing cardiac inflammation but not structural heart disease.

    • Valentina O. Puntmann
    • Simon Martin
    • Eike Nagel
    ResearchOpen Access
    Nature Medicine
    Volume: 28, P: 2117-2123

  • A role is demonstrated for miR-34a, a microRNA that is upregulated in the ageing heart; miR-34a downregulates PNUTS, a protein that protects cardiomyocytes and telomeres, silencing of miR-34a is therefore a promising therapeutic target.

    • Reinier A. Boon
    • Kazuma Iekushi
    • Stefanie Dimmeler
    Research
    Nature
    Volume: 495, P: 107-110

  • Hematopoiesis influences the progression of cardiovascular disease, yet the influence of cardiovascular disease on the bone vasculature is unknown. Hoffmann, Luxán, Abplanalp et al. describe the response of the bone cell composition to myocardial infarction and provide a rationale for using anti-inflammatory therapies to prevent the deterioration of the bone vascular niche

    • Jedrzej Hoffmann
    • Guillermo Luxán
    • Stefanie Dimmeler
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-11

  • The production of nitric oxide (NO) is required for early stage embryo implantation into the uterus. Here the authors show that during differentiation of naive mouse ESCs, early production of endogenous NO leads to a mesendoderm differentiation commitment pathway by inhibiting the action of the transcriptional repressor Zeb1.

    • Chiara Cencioni
    • Francesco Spallotta
    • Carlo Gaetano
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-15

  • Using large-scale single-nucleus transcriptomics, Nicin et al. report insights into human cardiac hypertrophy, caused by pressure overload, at single-cell resolution. The authors show that intercellular communication, particularly via the Eph receptor tyrosine kinase EPHB1, is impaired in human cardiomyopathy.

    • Luka Nicin
    • Sam Michael Schroeter
    • Stefanie Dimmeler
    ResearchOpen Access
    Nature Cardiovascular Research
    Volume: 1, P: 174-185

  • Genome-wide analyses identify variants near HDAC9 associated with abdominal aortic calcification and other cardiovascular phenotypes. Functional work shows that HDAC9 promotes an osteogenic vascular smooth muscle cell phenotype, enhancing calcification and reducing contractility.

    • Rajeev Malhotra
    • Andreas C. Mauer
    • Christopher J. O’Donnell
    Research
    Nature Genetics
    Volume: 51, P: 1580-1587

  • Blood and lymphatic vessels have essential roles in physiology and disease. The endothelial cells that line these vessels specialize to fulfil the needs of the tissue that they pervade. Recent studies in animal models have provided insights into the mechanisms underlying vessel type- and organ-specific specialization, which is crucial for the understanding of several diseases.

    • Michael Potente
    • Taija Mäkinen
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 18, P: 477-494