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Functional comparison of MERS-coronavirus lineages reveals increased replicative fitness of the recombinant lineage 5

MERS-CoV is enzootic in dromedary camels, can spread to humans but undergoes limited onward transmission. Here, Schroeder et al. compare clinical isolates of MERS-CoV in vitro and show that the predominantly circulating recombinant lineage 5 possess a fitness advantage over parental lineage 3 and 4 due to reduced activation of innate immune signaling.

Simon Schroeder
Christin Mache
Christian Drosten
ResearchOpen Access07 Sept 2021
Nature Communications

Volume: 12, P: 1-13
Compact zinc finger architecture utilizing toxin-derived cytidine deaminases for highly efficient base editing in human cells

The most recent class of base editors utilize DddAtox, a deaminase domain that can act upon double-stranded DNA. Here the authors target DddAtox fragments and a FokI-based nickase to the human CIITA gene by fusing these domains to arrays of engineered zinc fingers; they also identify a variety of DddAtox orthologues.

Friedrich Fauser
Bhakti N. Kadam
Jeffrey C. Miller
ResearchOpen Access15 Feb 2024
Nature Communications

Volume: 15, P: 1-11
Off-target-free gene delivery by affinity-purified receptor-targeted viral vectors

The clinical use of adeno-associated virus vectors (AAVs) has been limited by the lack of transduction specificity. Here the authors show that receptor-targeted, affinity-tagged, and purified AVVs reach tumours in mouse models with high selectivity and efficiency, outperforming therapeutic antibodies.

Robert C. Münch
Anke Muth
Christian J. Buchholz
Research10 Feb 2015
Nature Communications

Volume: 6, P: 1-9
Independent somatic evolution underlies clustered neuroendocrine tumors in the human small intestine

Small intestine neuroendocrine tumors (SI-NETs) are frequently multifocal and metastatic, but their tumourigenesis is still poorly understood. Here, the authors analyse multifocal SI-NET tumours with whole-genome sequencing, revealing the landscape of genomic alterations and frequent polyclonal origins.

Erik Elias
Arman Ardalan
Erik Larsson
ResearchOpen Access04 Nov 2021
Nature Communications

Volume: 12, P: 1-8
Influence of doping on charge carrier collection in normal and inverted geometry polymer:fullerene solar cells

George F. A. Dibb
Mathis-Andreas Muth
Jenny Nelson
ResearchOpen Access26 Nov 2013
Scientific Reports

Volume: 3, P: 1-7
Global phylogeography and evolutionary history of Shigella dysenteriae type 1

Global phylogenetic analyses of Shigella dysenteriae isolates uncover the transcontinental transmission events and evolution of antibiotic resistance behind the major dysentery epidemics in the modern era.

Elisabeth Njamkepo
Nizar Fawal
François-Xavier Weill
Research21 Mar 2016
Nature Microbiology

Volume: 1, P: 1-10
Temporal and spatial analysis of the 2014–2015 Ebola virus outbreak in West Africa

Analysis of 179 new Ebola virus sequences from patient samples collected in Guinea between March 2014 and January 2015 shows how different lineages evolved and spread in West Africa.

Miles W. Carroll
David A. Matthews
Stephan Günther
ResearchOpen Access17 Jun 2015
Nature

Volume: 524, P: 97-101
SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection

Here, Gassen et al. show that S-phase kinase-associated protein 2 (SKP2) is responsible for lysine-48-linked poly-ubiquitination of beclin 1, resulting in its proteasomal degradation, and that inhibition of SKP2 enhances autophagy and reduces replication of MERS coronavirus.

Nils C. Gassen
Daniela Niemeyer
Theo Rein
ResearchOpen Access18 Dec 2019
Nature Communications

Volume: 10, P: 1-16
Protein kinase CK2 enables regulatory T cells to suppress excessive T_H2 responses in vivo

The mechanisms that control the suppressive function of T_reg cells in specific tissues are unclear. Bopp and colleagues show that T_reg cells have high expression of kinase CK2 and this is critical for their ability to suppress type 2 responses in the lungs.

Alexander Ulges
Matthias Klein
Tobias Bopp
Research19 Jan 2015
Nature Immunology

Volume: 16, P: 267-275
Cytoplasmic HIF-2α as tissue biomarker to identify metastatic sympathetic paraganglioma

Sinan Karakaya
Lisa Gunnesson
Sofie Mohlin
ResearchOpen Access18 Jul 2023
Scientific Reports

Volume: 13, P: 1-12
Dynamic ligand binding dictates partial agonism at a G protein–coupled receptor

Partial agonists are generally thought to promote GPCR conformations that signal suboptimally. Analysis of bifunctional muscarinic M₂ receptor ligands now shows that partial agonism can also be predictably defined by a single ligand binding two receptor populations in different orientations.

Andreas Bock
Brian Chirinda
Klaus Mohr
Research10 Nov 2013
Nature Chemical Biology

Volume: 10, P: 18-20
Experimental imaging in orthotopic renal cell carcinoma xenograft models: comparative evaluation of high-resolution 3D ultrasonography, in-vivo micro-CT and 9.4T MRI

Johannes Linxweiler
Christina Körbel
Matthias Saar
ResearchOpen Access27 Oct 2017
Scientific Reports

Volume: 7, P: 1-10
Cytogenetic response to prior treatment with interferon-α is predictive for survival after allogeneic hematopoietic stem cell transplantation in chronic myeloid leukemia

O Maywald
M Pfirrmann
A Reiter
Research02 Feb 2006
Leukemia

Volume: 20, P: 477-484

Search

Functional comparison of MERS-coronavirus lineages reveals increased replicative fitness of the recombinant lineage 5

Compact zinc finger architecture utilizing toxin-derived cytidine deaminases for highly efficient base editing in human cells

Off-target-free gene delivery by affinity-purified receptor-targeted viral vectors

Independent somatic evolution underlies clustered neuroendocrine tumors in the human small intestine

Influence of doping on charge carrier collection in normal and inverted geometry polymer:fullerene solar cells

Global phylogeography and evolutionary history of Shigella dysenteriae type 1

Temporal and spatial analysis of the 2014–2015 Ebola virus outbreak in West Africa

SKP2 attenuates autophagy through Beclin1-ubiquitination and its inhibition reduces MERS-Coronavirus infection

Protein kinase CK2 enables regulatory T cells to suppress excessive T_H2 responses in vivo

Cytoplasmic HIF-2α as tissue biomarker to identify metastatic sympathetic paraganglioma

Dynamic ligand binding dictates partial agonism at a G protein–coupled receptor

Experimental imaging in orthotopic renal cell carcinoma xenograft models: comparative evaluation of high-resolution 3D ultrasonography, in-vivo micro-CT and 9.4T MRI

Cytogenetic response to prior treatment with interferon-α is predictive for survival after allogeneic hematopoietic stem cell transplantation in chronic myeloid leukemia

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