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Showing 1–3 of 3 results
Advanced filters: Author: Andreja Majerle Clear advanced filters

  • Toggle switches can be engineered using pairs of transcriptional repressors; however, their bistability depends on nonlinear DNA-binding properties. Lebar et al. design a circuit that ensures bistability by artificially generating nonlinearity and use it to construct a toggle from programmable DNA-binding domains.

    • Tina Lebar
    • Urban Bezeljak
    • Roman Jerala
    Research
    Nature Communications
    Volume: 5, P: 1-13

  • Synthetic biology requires orthogonal inputs and outputs to avoid undesired crosstalk between genetic constructs. Transcription activator–like effectors (TALEs), which bind diverse DNA sequences and can thus be orthogonal, are now employed to construct NOR gates and logic circuits in mammalian cells.

    • Rok Gaber
    • Tina Lebar
    • Roman Jerala
    Research
    Nature Chemical Biology
    Volume: 10, P: 203-208