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Showing 1–4 of 4 results
Advanced filters: Author: Andrew A. Guirguis Clear advanced filters

  • Conditional Degron Tags are a valuable tool to validate and study novel therapeutic targets. Here, the authors compared 5 orthogonal tags across 16 unique proteins and provide a panel of vectors for users to systematically screen the tags with their own protein of interest.

    • Daniel P. Bondeson
    • Zachary Mullin-Bernstein
    • Alessandra Ianari
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • Binding of the small molecule BI-3802 to the oncogenic transcription factor B cell lymphoma 6 (BCL6) induces polymerization of BCL6, leading to its ubiquitination by SIAH1 and proteasomal degradation.

    • Mikołaj Słabicki
    • Hojong Yoon
    • Benjamin L. Ebert
    Research
    Nature
    Volume: 588, P: 164-168

  • Cell cycle kinetics of pre-leukemic stem cells (pre-LSCs) may be an important determinant of clonal evolution and therapeutic resistance. Here, the AUs use a transgenic T-ALL mouse model that allows non-dividing cells to be tracked and identify a subset of non-dividing pre-LSCs maintained by p21.

    • Cedric S. Tremblay
    • Jesslyn Saw
    • David J. Curtis
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13