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Showing 1–11 of 11 results
Advanced filters: Author: Andrew D. McAinsh Clear advanced filters

  • Astral microtubules emanating from the spindle poles engage force-generating proteins such as dynein at the cell cortex to regulate spindle positioning. McAinsh and colleagues show that the microtubule-associated proteins MAP4 and CLASP1 control the interactions of astral microtubules at the cell cortex to ensure correct spindle positioning.

    • Catarina P. Samora
    • Binyam Mogessie
    • Andrew D. McAinsh
    Research
    Nature Cell Biology
    Volume: 13, P: 1040-1050

  • The core kinetochore protein CENP-H is shown to be required for the organization of the metaphase plate. CENP-H regulates microtubule plus-end dynamics, and chromosome oscillations, which are shown to be essential for chromosome congression.

    • Ana C. Amaro
    • Catarina P. Samora
    • Patrick Meraldi
    Research
    Nature Cell Biology
    Volume: 12, P: 319-329

  • Microtubules are built from GDP-tubulin lattices with small GTP caps at their plus-ends. Here, the authors reveal that microtubules that attach to kinetochores in mitosis contain, in addition to the GTP-cap and the GDP-lattices, a dynamic micron-sized mixed-nucleotide zone.

    • Cédric Castrogiovanni
    • Alessio V. Inchingolo
    • Patrick Meraldi
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-16

  • Single microtubules (MTs) can move chromosomes, but it is unclear why kinetochores bind up to 20 MTs. Here, the authors decrease the number of kinetochore MTs with BAL27862 and see lagging chromosomes, suggesting that numerous kinetochore MTs provide force ensuring robust chromosomal segregation.

    • Damian Dudka
    • Anna Noatynska
    • Patrick Meraldi
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-16

  • Human beings arise from serial mitotic divisions of a single fertilised egg. Here through live cell imaging of fertilized embryos the authors show that the first mitotic division is error prone and can contribute to preimplantation mosaicism.

    • Cerys E. Currie
    • Emma Ford
    • Andrew D. McAinsh
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • Microplastic concentrations in agricultural soils increased at higher rates between 1966 and 2022 when farm manure and inorganic fertilizers were added than when soils were not amended, suggests an analysis of soil samples from the Broadbalk winter wheat experiment in the United Kingdom.

    • Samuel J. Cusworth
    • William J. Davies
    • Carly J. Stevens
    ResearchOpen Access
    Communications Earth & Environment
    Volume: 5, P: 1-5

  • The detailed motor mechanisms of individual kinesin family members are described in the context of their interactions with dynamic microtubules, and their contributions to important mechanistic events during bipolar spindle assembly and chromosome segregation in animal cells.

    • Robert A. Cross
    • Andrew McAinsh
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 15, P: 257-271

  • The spindle assembly checkpoint (SAC) ensures correct chromosome segregation during mitosis by inhibiting anaphase until all kinetochores are attached to microtubules. Recent studies highlight the dynamic properties of SAC signalling and begin to explain signal integration at mammalian kinetochores, which feature multiple attachment points.

    • Andrew D. McAinsh
    • Geert J. P. L. Kops
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 24, P: 543-559

  • Three microtubule nucleation pathways — initiated from centrosomes, chromatin and existing spindle microtubules — contribute to the assembly of a functional mitotic spindle in animal cells to ensure accurate chromosome segregation. Recent findings have shed light on their relative contributions to building the spindle and on adaptation of the spindle to variations in cell size and shape.

    • Suzanna L. Prosser
    • Laurence Pelletier
    Reviews
    Nature Reviews Molecular Cell Biology
    Volume: 18, P: 187-201