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Showing 1–5 of 5 results
Advanced filters: Author: Andrew M. Giltrap Clear advanced filters

  • The modification of peptides and proteins for application in drug discovery and chemical biology is currently a rapidly growing field of research. Here, the authors report a photocatalytic diselenide contraction method for the dimerization and site-specific functionalisation of peptides and protein.

    • Luke J. Dowman
    • Sameer S. Kulkarni
    • Richard J. Payne
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-12

  • Drug resistant tuberculosis (TB) infections are emerging at a high rate, with only few therapeutic options currently available. Here, the authors report synthetic analogues of the natural product sansanmycin that target mycobacterial cell wall biosynthesis and represent potent leads for improved anti-TB treatments.

    • Anh T. Tran
    • Emma E. Watson
    • Richard J. Payne
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-9

  • Post-translational site-selective formation of boronoalanine in proteins enables applications of boron for binding partner capture, footprinting of interactions with reactive oxygen species, proteolytic control and mapping of transient structures.

    • Tim A. Mollner
    • Patrick G. Isenegger
    • Benjamin G. Davis
    ResearchOpen Access
    Nature Chemical Biology
    Volume: 17, P: 1245-1261