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Showing 1–14 of 14 results

Advanced filters: Author: Andrew Plested Clear advanced filters

Superactivation of AMPA receptors by auxiliary proteins

Transmembrane AMPA receptor regulatory proteins (TARPs) exert a number of effects on fast glutamatergic synaptic transmission. Here, the authors model the interactions of two such proteins, Stargazin and γ-8, and propose a simple kinetic mechanism by which TARPs modulate channel opening reaction.

Anna L. Carbone
Andrew J. R. Plested
ResearchOpen Access08 Jan 2016
Nature Communications

Volume: 7, P: 1-12
Glutamate receptor complexes open up and reveal their molecular dialect

AMPA receptors are a class of protein complexes crucial for neuronal communication. Two complementary studies converge on structures of AMPA receptors found in a brain region called the hippocampus.

Andrew J. R. Plested
News & Views02 Jun 2021
Nature

Volume: 594, P: 338-339
Author Correction: Calcium-permeable channelrhodopsins for the photocontrol of calcium signalling

Rodrigo G. Fernandez Lahore
Niccolò P. Pampaloni
Peter Hegemann
Amendments and CorrectionsOpen Access10 May 2024
Nature Communications

Volume: 15, P: 1
How to button a bouton with α₂δs

The α₂δ-3 auxiliary subunit of voltage-dependent calcium channels promotes the formation of synaptic boutons in Drosophila neuromuscular junction independently of its role in channel localization.

Stephan J Sigrist
Andrew J R Plested
News & Views01 Nov 2009
Nature Neuroscience

Volume: 12, P: 1357-1358
Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses

Two doses of the coronavirus disease 2019 vaccine ChAdOx1 nCoV-19 boost antibody responses and functions in phase 1/2 trial participants.

Jordan R. Barrett
Sandra Belij-Rammerstorfer
Dalila Zizi
Research17 Dec 2020
Nature Medicine

Volume: 27, P: 279-288
Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 lineages circulating in Brazil

Emerging variants of SARS-CoV-2 raise concerns about vaccine efficiency. Here, the authors present a post-hoc analysis for the ChAdOx1 nCoV-19 (AZD1222) vaccine trial in Brazil and provide efficacy against symptomatic COVID-19 caused by the Zeta (P.2) and other variants.

Sue Ann Costa Clemens
Pedro M. Folegatti
Rafael Zimmer
ResearchOpen Access06 Oct 2021
Nature Communications

Volume: 12, P: 1-10
Correlates of protection against symptomatic and asymptomatic SARS-CoV-2 infection

Defined levels of SARS-CoV-2-specific binding and neutralizing antibodies elicited by the COVID-19 vaccine ChAdOx1 nCoV-19 are identified as correlates of protection against symptomatic infection.

Shuo Feng
Daniel J. Phillips
Christopher J. Williams
ResearchOpen Access29 Sept 2021
Nature Medicine

Volume: 27, P: 2032-2040
Author Correction: Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses

Jordan R. Barrett
Sandra Belij-Rammerstorfer
Dalila Zizi
Amendments and Corrections06 May 2021
Nature Medicine

Volume: 27, P: 1113
Mechanism of partial agonism in AMPA-type glutamate receptors

Partial agonists weakly activate receptors even when occupying all available binding sites. Here the authors show that partial agonists of the AMPA receptor drive the adoption of multiple inactive forms, accounting for their limited efficacy.

Hector Salazar
Clarissa Eibl
Andrew Plested
ResearchOpen Access17 Feb 2017
Nature Communications

Volume: 8, P: 1-11
An optogenetic method for the controlled release of single molecules

An optogenetic system enables the controlled release of soluble and transmembrane proteins for precise exploration of cellular protein function at the single-molecule level and streamlined single-molecule imaging.

Purba Kashyap
Sara Bertelli
Helge Ewers
ResearchOpen Access08 Mar 2024
Nature Methods

Volume: 21, P: 666-672
Author Correction: T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial

Katie J. Ewer
Jordan R. Barrett
Elizabeth Stafford
Amendments and Corrections21 May 2021
Nature Medicine

Volume: 27, P: 1116
Calcium-permeable channelrhodopsins for the photocontrol of calcium signalling

To date, no Ca2 + -selective channelrhodopsins have been characterized. In this study, Fernandez Lahore et al. report two calcium-permeable channelrhodopsins (CapChR1 and 2) for the photocontrol of calcium signalling in excitable tissue.

Rodrigo G. Fernandez Lahore
Niccolò P. Pampaloni
Peter Hegemann
ResearchOpen Access21 Dec 2022
Nature Communications

Volume: 13, P: 1-18
T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial

A single dose of the ChAdOx1 nCoV-19 vaccine elicits antibodies and cytokine-producing T cells that might help control or prevent SARS-CoV-2 infection.

Katie J. Ewer
Jordan R. Barrett
Elizabeth Stafford
Research17 Dec 2020
Nature Medicine

Volume: 27, P: 270-278
Structural mechanisms of activation and desensitization in neurotransmitter-gated ion channels

Numerous recent crystal and cryo-EM structures have greatly advanced understanding of the functional mechanisms of neurotransmitter-gated ion channels. This Review discusses the structural basis of activation and desensitization mechanisms in glutamate and cysteine-loop receptors.

Andrew J R Plested
Reviews07 Jun 2016
Nature Structural & Molecular Biology

Volume: 23, P: 494-502