Recent research indicates that the Notch signalling pathway is important for directing T helper (TH)-cell differentiation. In this Review, the authors discuss contrasting results showing that Notch can have a role in both TH1- and TH2-cell differentiation, and highlight how this information might help to better understand the pathology of T-cell-mediated diseases.
- Derk Amsen
- Andrey Antov
- Richard A. Flavell
