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Fruit and vegetable supply in the United Kingdom has increasingly been characterized by reduced domestic production of fruit and vegetables and increased reliance on imports from climate-vulnerable countries. With increasing climate change, this may impact availability, price and consumption of fruit and vegetables in the UK, with health consequences, particularly for older people and low-income households.

Wansheng Jiang studies the endangered Chinese giant salamander to better protect its habitat.

The mechanism underlying the cellular entry of Zika virus is not fully understood. Here, the authors use a chemically modified virus and time-resolved proteomics to capture interacting host proteins during virus entry and identify NCAM1 as a ZIKV receptor.

Using lipid residues absorbed in potsherds, the ages of pottery from various archaeological sites are determined and validated using sites for which the dates are well known from other methods.

In this Perspective, members of the Aging Biomarker Consortium outline the X-Age Project, an Aging Biomarker Consortium plan for building standardized aging clocks in China. The authors discuss the project roadmap and its aims of decoding aging heterogeneity, detecting accelerated aging early and evaluating geroprotective interventions.

Mutualistic interactions involve trading benefits between cooperative species. Here, the authors show that restricting the resource acquisition of a mutualistic partner can increase mutualism by promoting resource trade, which suggests that conflict may lead to increased cooperation.

Here, the authors describe the global distribution of crAssphage, its presence in Old-World and New-World primates, and its association with gut bacterial communities and dietary factors, providing insights into the origin, evolution and epidemiology of human gut crAssphage.

Post injury cytoskeletal modifications in neurons are not fully understood. Here the authors describe a pro-survival actin cytoskeletal reorganization in neurons triggered during a model of ischemic stroke.

The integration of barium titanate thin films with silicon-based waveguides enables the operation of efficient electro-optic switches and modulators at temperatures as low as 4 K, with potential applications in quantum computing and cryogenic computing technologies.

The influence of biodiversity on multiple ecosystem processes is not well understood. Analysing 94 biodiversity-ecosystem functioning experiments, Lefcheck et al. find that increased species richness maintains more ecological functions, across multiple taxa, trophic levels and habitats.

Analysis of mitochondrial genomes (mtDNA) by using whole-genome sequencing data from 2,658 cancer samples across 38 cancer types identifies hypermutated mtDNA cases, frequent somatic nuclear transfer of mtDNA and high variability of mtDNA copy number in many cancers.

Climate-driven periodicity of flowstone accretion between 3.2 and 1.3 million years ago in Cradle of Humankind caves reveals that the presence of hominin fossils reflects accumulation in open caves during intermittent, substantially drier phases.

In this study, Aggarwal and colleagues perform prospective sequencing of SARS-CoV-2 isolates derived from asymptomatic student screening and symptomatic testing of students and staff at the University of Cambridge. They identify important factors that contributed to within university transmission and onward spread into the wider community.

The ventral hippocampal CA3 and CA1 subfields play a critical role in the resolution of approach-avoidance conflict. Here the authors show that the subfields contribute to the regulation of this behavior through topographically distinct projections to the lateral septum.

Transcriptomic analysis of BCR-ABL1 lymphoblastic leukemia identifies three subgroups, each associated with a maturation arrest at a specific stage of B-cell progenitor differentiation and distinct genetic and clinical features.

Qiu et al. show that chronic interferon (IFN) stimulation establishes an epigenetic signature of inflammatory memory in tumor cells, resulting in elevated levels of IFN-stimulated genes that sustain immune cell dysfunction when IFN is low.

Most of the archaeological record of the Middle to Later Stone Age transition comes from southern Africa. Here, Shipton et al. describe the new site Panga ya Saidi on the coast of Kenya that covers the last 78,000 years and shows gradual cultural and technological change in the Late Pleistocene.

KSR1 interacts with and regulates YAP co-transcriptional function, revealing an additional mechanism for growth control and tumourigenesis.

Dog vaccination is an effective rabies prevention measure, but widespread vaccination campaigns are challenging in settings like India with large free-roaming dog populations. Here, the authors describe a One Health campaign in Goa state which led to a large reduction of cases in dogs and elimination in humans.

Eutrophication has been shown to weaken diversity-stability relationships in grasslands, but it is unclear whether the effect depends on scale. Analysing a globally distributed network of grassland sites, the authors show a positive role of beta diversity and spatial asynchrony as drivers of stability but find that nitrogen enrichment weakens the diversity-stability relationships at different spatial scales.

Chronic infection with SARS-CoV-2 leads to the emergence of viral variants that show reduced susceptibility to neutralizing antibodies in an immunosuppressed individual treated with convalescent plasma.

How biodiversity is linked to multiple ecosystem functions is not fully understood. Here, the authors show that a new mechanism, which they term the 'jack-of-all-trades' effect, best explains patterns of tree diversity and ecosystem multifunctionality in European forests.

Analysing data from 39 grassland biodiversity experiments, the authors uncover the direct and indirect contributions to ecosystem stability of taxonomic, phylogenetic and functional trait diversity.

Sera from vaccinated individuals and some monoclonal antibodies show a modest reduction in neutralizing activity against the B.1.1.7 variant of SARS-CoV-2; but the E484K substitution leads to a considerable loss of neutralizing activity.

Solid oxide-ion conductors are crucial components in many energy and environment technologies. Here, the authors produce La₂Mo₂O₉nanowires with high ionic conductivity which is attributed to both the stabilization of the high-temperature phase and excess conduction in the disordered surface phases.

In vertebrate embryos, Wnt/β-catenin signaling induces an organizer area guiding the formation of body axes and inducing extra axes upon transplantation. Here, Kraus et al. show that Wnt ligands also induce an organizer in a sea anemone, indicating that the organizer dates back over 600 million years.

It is feared that reprogramming may introduce DNA mutations. Here Bhutani et al. take three different reprogramming methods and using comparative whole genome analyses do identify nucleotide variations that are different in reprogrammed cells from the original fibroblasts, but none convey oncogenic potential.

A first-in-human phase I clinical trial demonstrates the feasibility and safety of non-viral precision genome-engineering of a personalized adoptive cell transfer anticancer therapeutic.

The authors demonstrate a multi-dimensional communication scheme that combines wavelength- and mode- multiplexing on photonic integrated circuits using foundry-compatible photonic inverse design and spectrally flattened microcombs

This work reveals the structural and biochemical basis for phosphorylation-dependent day/night signaling by KaiC in the cyanobacterial circadian clock.

Intensive efforts are underway to develop recycling methods for spent lithium-ion batteries. Here the authors develop a mechano-catalytic approach based on contact electrification for efficient and potentially cost-effective recycling of cathode materials.

A novel gene expression classifier of AML heterogeneity captures patient-specific variation in leukemia cell composition and predicts clinical responses to treatment.

Investigations of an Icelandic volcanic eruption confirm that sulfate aerosols caused a discernible yet transient brightening effect, as predicted, but their effect on the liquid water path was unexpectedly negligible.

Emerging variants of SARS-CoV-2 raise concerns about vaccine efficiency. Here, the authors present a post-hoc analysis for the ChAdOx1 nCoV-19 (AZD1222) vaccine trial in Brazil and provide efficacy against symptomatic COVID-19 caused by the Zeta (P.2) and other variants.

An ensemble of climate model simulations, as well as hydrological modelling and flood risk mapping, are used to show the role of anthropogenic warming on the extreme rainfall that caused the 2013/14 floods in southern England.

Associations with mycorrhizal fungi can affect the outcome of plant competition in complex ways. Here the authors use a decade-long field survey and two hyphal exclusion experiments to reveal a critical role of underground fungal networks in facilitating seedling growth and fitness of ectomycorrhizal plants but not arbuscular mycorrhizal plants.

An integrated transcriptome, genome, methylome and proteome analysis of over 200 lung adenocarcinomas reveals high rates of somatic mutations, 18 statistically significantly mutated genes including RIT1 and MGA, splicing changes, and alterations in MAPK and PI(3)K pathway activity.

Deep-sea diving mammals routinely undergo extreme physiological challenges not experienced by their terrestrial counterparts. Using high-resolution electrocardiographic recorders fitted to seals and dolphins, Williams et al. report an increased frequency of cardiac arrhythmias at greater exercise intensity and dive depth.

Oxygen has long been considered as a detrimental impurity in pure titanium since it can severely deteriorate the ductility. Here, the authors propose a simple, yet effective strategy via grain refinement to solve this long-standing issue, while preserving its potential hardening effect.

Between around 5,000 to 2,000 years ago, a drying climate in the vast peatlands of the Congo Basin triggered peat decomposition and carbon release to the atmosphere, implying that this region may be vulnerable to future climate change.

Here the authors present improved intramolecular sensors for β-arrestin2 and 1, which enable assessment of conformational changes of both isoforms in living cells. These reveal that the same GPCR induces differential conformational rearrangements that determine the functional diversity between the two β-arrestins.

Computational modeling and design of G Protein-Coupled Receptor quaternary structures reveals a signaling bias switch at the receptor dimer interface that selectively controls G protein vs β-arrestin activation.

A spatially resolved transcriptional atlas of the mid-gestational developing human brain has been created using laser-capture microdissection and microarray technology, providing a comprehensive reference resource which also enables new hypotheses about the nature of human brain evolution and the origins of neurodevelopmental disorders.

Glacially-derived iron fertilizes the Southern Ocean ecosystem, but the quantities transported by runoff from Antarctica are unknown. Here, the authors show significant fluxes associated with surface meltwater runoff, and demonstrate that a marked increase in export can be expected in response to climate warming.

The Cancer Genome Atlas reports on molecular evaluation of 295 primary gastric adenocarcinomas and proposes a new classification of gastric cancers into 4 subtypes, which should help with clinical assessment and trials of targeted therapies.

A genome-wide association study of critically ill patients with COVID-19 identifies genetic signals that relate to important host antiviral defence mechanisms and mediators of inflammatory organ damage that may be targeted by repurposing drug treatments.

Quantifying Greenland's future contribution to sea level requires accurate portrayal of its outlet glaciers in ice sheet simulations. Here, the authors show that outlet glacier flow can be captured if ice thickness is well constrained and vertical shearing as well as membrane stresses are included in the model.