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Showing 1–4 of 4 results
Advanced filters: Author: Andy Christoforou Clear advanced filters

  • This protocol describes a substantially redeveloped approach for the localization of organelle proteins by isotope tagging (LOPIT) to enable subcellular localization of thousands of proteins per experiment (hyperLOPIT).

    • Claire M Mulvey
    • Lisa M Breckels
    • Kathryn S Lilley
    Protocols
    Nature Protocols
    Volume: 12, P: 1110-1135

  • The spatial location of proteins within a cell is a key element of protein function. Here the authors describe hyperLOPIT—a proteomics workflow that allows the simultaneous assignment of thousands of proteins to subcellular niches with high resolution—and apply it to mouse pluripotent stem cells.

    • Andy Christoforou
    • Claire M. Mulvey
    • Kathryn S. Lilley
    ResearchOpen Access
    Nature Communications
    Volume: 7, P: 1-12

  • Isobaric tagging methods allow multiplexed quantitative analysis of a wide variety of proteome samples but have been severely limited by problems of accuracy. Two groups now explore this issue and provide complementary solutions to address the problem.

    • Andy Christoforou
    • Kathryn S Lilley
    News & Views
    Nature Methods
    Volume: 8, P: 911-913

  • “Protein relocalisation plays a major role in the innate immune response but remains incompletely characterised. Here, the authors combine temporal proteomics with LOPIT, a spatial proteomic workflow, in a fully Bayesian framework to elucidate spatiotemporal proteomic changes during the LPS-induced immune response in THP-1 cells.

    • Claire M. Mulvey
    • Lisa M. Breckels
    • Kathryn S. Lilley
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-19