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Advanced filters: Author: Angélica Olmo-Fontánez Clear advanced filters

  • Here, the authors characterize tissue-level SARS-CoV-2 infection and pathogenesis in transgenic mice expressing human angiotensin converting enzyme 2 (hACE2) by the human cytokeratin 18 promoter (K18-hACE2) and show that infection induces lethality, making the K18-hACE2 model suitable for vaccine and therapeutic evaluation.

    • Fatai S. Oladunni
    • Jun-Gyu Park
    • Jordi B. Torrelles
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-17