Nature Search

Ultra-long-acting in-situ forming implants with cabotegravir protect female macaques against rectal SHIV infection

In this study, the authors developed an ultra-long-acting injectable, biodegradable, and removable in-situ forming implant delivering cabotegravir (CAB ISFI). CAB ISFI was well tolerated and protected against multiple rectal SHIV challenges in female macaques.

Isabella C. Young
Ivana Massud
S. Rahima Benhabbour
ResearchOpen Access09 Feb 2023
Nature Communications

Volume: 14, P: 1-15
Ultra-long-acting tunable biodegradable and removable controlled release implants for drug delivery

Patient drug regime compliance is a major issue; sustained release implants could address this. Here, the authors report on a phase inverted in situ forming implant of PLGA for the sustained release of antiretroviral drugs and optimize and demonstrate the release of 6 different drugs over a period of up to a year.

S. Rahima Benhabbour
Martina Kovarova
J. Victor Garcia
ResearchOpen Access20 Sept 2019
Nature Communications

Volume: 10, P: 1-12
Ultra-long-acting removable drug delivery system for HIV treatment and prevention

Long-acting (LA) formulations of antiretroviral (ARV) drugs are an alternative approach to improve adherence for HIV treatment and prevention. Here the authors show a removable biodegradable ultra-LA-ARV drug system that effectively delivers drug, controls viremia and prevents infection in animal models of HIV infection.

Martina Kovarova
S. Rahima Benhabbour
J. Victor Garcia
ResearchOpen Access08 Oct 2018
Nature Communications

Volume: 9, P: 1-11
Genital inflammation undermines the effectiveness of tenofovir gel in preventing HIV acquisition in women

In the absence of genital inflammation, tenofovir gel provides superior prevention against HIV acquisition in women.

Lyle R McKinnon
Lenine J Liebenberg
Jo-Ann S Passmore
Research26 Feb 2018
Nature Medicine

Volume: 24, P: 491-496
Author Correction: Ultra-long-acting in-situ forming implants with cabotegravir protect female macaques against rectal SHIV infection

Isabella C. Young
Ivana Massud
S. Rahima Benhabbour
Amendments and CorrectionsOpen Access05 Feb 2024
Nature Communications

Volume: 15, P: 1
CCR5 inhibitor as novel acute graft versus host disease prophylaxis in children and young adults undergoing allogeneic stem cell transplant: results of the phase II study

Pooja Khandelwal
Tsuyoshi Fukuda
Stella M. Davies
Research09 Apr 2020
Bone Marrow Transplantation

Volume: 55, P: 1552-1559
Bottlenecks in HIV-1 transmission: insights from the study of founder viruses

HIV-1 infection typically results from the transmission of a single viral variant, the transmitted/founder (T/F) virus. In this Review, Joseph and colleagues discuss how studying these T/F viruses contributes to a better understanding of HIV-1 transmission and affects prevention strategies.

Sarah B. Joseph
Ronald Swanstrom
Myron S. Cohen
Reviews08 Jun 2015
Nature Reviews Microbiology

Volume: 13, P: 414-425
Predicting HIV Pre-exposure Prophylaxis Efficacy for Women using a Preclinical Pharmacokinetic-Pharmacodynamic In Vivo Model

Angela Wahl
Phong T. Ho
J. Victor Garcia
ResearchOpen Access01 Feb 2017
Scientific Reports

Volume: 7, P: 1-11
Hormonal Contraceptives Differentially Suppress TFV and TAF Inhibition of HIV Infection and TFV-DP in Blood and Genital Tract CD4+ T cells

Zheng Shen
Marta Rodriguez-Garcia
Charles R. Wira
ResearchOpen Access18 Dec 2017
Scientific Reports

Volume: 7, P: 1-12

Search

Ultra-long-acting in-situ forming implants with cabotegravir protect female macaques against rectal SHIV infection

Ultra-long-acting tunable biodegradable and removable controlled release implants for drug delivery

Ultra-long-acting removable drug delivery system for HIV treatment and prevention

Genital inflammation undermines the effectiveness of tenofovir gel in preventing HIV acquisition in women

Author Correction: Ultra-long-acting in-situ forming implants with cabotegravir protect female macaques against rectal SHIV infection

CCR5 inhibitor as novel acute graft versus host disease prophylaxis in children and young adults undergoing allogeneic stem cell transplant: results of the phase II study

Bottlenecks in HIV-1 transmission: insights from the study of founder viruses

Predicting HIV Pre-exposure Prophylaxis Efficacy for Women using a Preclinical Pharmacokinetic-Pharmacodynamic In Vivo Model

Hormonal Contraceptives Differentially Suppress TFV and TAF Inhibition of HIV Infection and TFV-DP in Blood and Genital Tract CD4+ T cells

Search

Quick links

Search

Filter By:

Search

Quick links