Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–4 of 4 results
Advanced filters: Author: Angela Richard-Londt Clear advanced filters

  • Prions (PrP) are infectious agents that cause lethal neurodegenerative diseases. Here the authors study the kinetics of prion propagation in mice and show that the onset of neuropathology occurs during the late phase of disease and is hypothesized to be due to increases in a toxic isoform of PrP that is different from the infectious species.

    • Malin K. Sandberg
    • Huda Al-Doujaily
    • John Collinge
    ResearchOpen Access
    Nature Communications
    Volume: 5, P: 1-7

  • In utero GBA gene therapy extends lifespan and provides long-lasting phenotypic amelioration in a mouse model of neuronopathic Gaucher disease. Fetal ultrasound-guided in utero gene vector delivery is also achieved in the non-human primate brain.

    • Giulia Massaro
    • Citra N. Z. Mattar
    • Ahad A. Rahim
    Research
    Nature Medicine
    Volume: 24, P: 1317-1323

  • This study looks at a polymorphism of the human prion protein gene, which results in a G-to-V substitution at residue 127, in transgenic mice expressing different human prion proteins, finding that mice heterozygous for the G127V polymorphism are resistant to both kuru and classical CJD prions, but there is some transmission of variant CJD prions; most remarkable, however, is that mice homozygous for V127 are completely resistant to all prion strains.

    • Emmanuel A. Asante
    • Michelle Smidak
    • John Collinge
    Research
    Nature
    Volume: 522, P: 478-481