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Showing 1–3 of 3 results
Advanced filters: Author: Angelia V. Bassenden Clear advanced filters

  • Golkar, Bassenden et al. report two structures of the latest generation aminoglycoside antibiotic plazomicin in complex with the bacterial 70S ribosome as well as in complex with AAC(2’)-la acetyltransferase, an antibiotic modification enzyme (AME). Their study can be useful in the development of newer aminoglycosides that are not modified by AMEs while being capable of targeting the bacterial ribosome.

    • Tolou Golkar
    • Angelia V. Bassenden
    • Albert M. Berghuis
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-8

  • Giant cell lesions of the jaw (GCLJ) are debilitating benign tumors of unclear origin. The authors identify driver recurrent somatic mutations in TRPV4, KRAS and FGFR1 and show they converge on aberrant activation of the MAPK pathway. Their findings extend the spectrum of TRPV4 channelopathies and provide rationale for targeted therapies at the bedside in GCLJ.

    • Carolina Cavalieri Gomes
    • Tenzin Gayden
    • Nada Jabado
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-8